Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network

  1. Diana Martinez
  2. Haroon Anwar
  3. Amitabha Bose
  4. Dirk M Bucher
  5. Farzan Nadim  Is a corresponding author
  1. New Jersey Institute of Technology, United States

Abstract

In oscillatory systems, neuronal activity phase is often independent of network frequency. Such phase maintenance requires adjustment of synaptic input with network frequency, a relationship that we explored using the crab, Cancer borealis, pyloric network. The burst phase of pyloric neurons is relatively constant despite a >2-fold variation in network frequency. We used noise input to characterize how input shape influences burst delay of a pyloric neuron, and then used dynamic clamp to examine how burst phase depends on the period, amplitude, duration, and shape of rhythmic synaptic input. Phase constancy across a range of periods required a proportional increase of synaptic duration with period. However, phase maintenance was also promoted by an increase of amplitude and peak phase of synaptic input with period. Mathematical analysis shows how short-term synaptic plasticity can coordinately change amplitude and peak phase to maximize the range of periods over which phase constancy is achieved.

Data availability

Source data files have been provided for Figures 2 and 7.

Article and author information

Author details

  1. Diana Martinez

    Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Haroon Anwar

    Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3079-4812
  3. Amitabha Bose

    Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. Dirk M Bucher

    Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, United States
    Competing interests
    The authors declare that no competing interests exist.
  5. Farzan Nadim

    Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, United States
    For correspondence
    farzan@njit.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-4144-9042

Funding

National Institutes of Health (MH060605)

  • Dirk M Bucher
  • Farzan Nadim

National Science Foundation (DMS1122291)

  • Amitabha Bose

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Ronald L Calabrese, Emory University, United States

Publication history

  1. Received: March 15, 2019
  2. Accepted: June 8, 2019
  3. Accepted Manuscript published: June 10, 2019 (version 1)
  4. Version of Record published: June 24, 2019 (version 2)

Copyright

© 2019, Martinez et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Diana Martinez
  2. Haroon Anwar
  3. Amitabha Bose
  4. Dirk M Bucher
  5. Farzan Nadim
(2019)
Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
eLife 8:e46911.
https://doi.org/10.7554/eLife.46911

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