(A) The pattern of AmF fibers is preserved across the two species and predominantly targets medial areas in subgenual, orbital, ventral, and polar PFC. (B) Overall, UF axons show high similarity between the two species, but stronger innervation to the opercular and insular cortex is observable in the human UF. (C–E) Macaque–human comparison of the prefrontal fibers organization of three connectional systems located in the white matter dorsal to the AmF (internal capsule; C), dorsal to the UF (extreme capsule; D) or interacting with both tracts in the infralimbic and prelimbic cortex (cingulum bundle; E). 9 m, dorsomedial PFC; 8 m, caudal bank of the dorsomedial PFC; 32, anterior cingulate cortex; 25, subgenual cingulate cortex; 24, dorsal anterior cingulate cortex; preSMA, pre-supplementary motor area; IFGtr, inferior frontal gyrus, pars triangularis; FOp, frontal operculum; Ins, insular cortex; 14 m, ventromedial PFC; 13, caudal orbitofrontal cortex; 11, rostral orbitofrontal cortex; 47 (human) or 47/12 (macaque) lateral orbitofrontal cortex (also named lateral convexity in Murray and Rudebeck, 2018 and in Rudebeck and Murray, 2014); 10 l, lateral frontopolar cortex; 10 m, medial frontopolar cortex; 44, caudal bank of the ventrolateral PFC; 45, rostral bank of the ventrolateral PFC. Shades represent standard error of the mean (SEM).