1. Cell Biology
  2. Human Biology and Medicine
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Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

  1. Kasparas Petkevicius  Is a corresponding author
  2. Sam Virtue
  3. Guillaume Bidault
  4. Benjamin Jenkins
  5. Cankut Çubuk
  6. Cecilia Morgantini
  7. Myriam Aouadi
  8. Joaquin Dopazo
  9. Mireille Serlie
  10. Albert Koulman
  11. Antonio Vidal-Puig  Is a corresponding author
  1. University of Cambridge, United Kingdom
  2. Fundacion Progreso y Salud, Spain
  3. Karolinska Institute, Sweden
  4. Amsterdam University Medical Center, Netherlands
Research Article
Cite this article as: eLife 2019;8:e47990 doi: 10.7554/eLife.47990
2 data sets and 1 additional file

Data availability

We are submitting raw source data excel file for LC-MS lipidomics of Pcyt1a-deficient BMDMs, in both palmitate-treated and basal states (containing peak areas for each lipid species normalized to peak areas of respective internal standards) as Figure 6-source data 1.ATM microarray dataset (GSE36669) used in Figure 1 is already published and referenced in this manuscript.We are also submitting a list of differentially expressed genes detected by RNAseq in the eWAT of ob/ob bone marrow transplant mice, with a log (Fold change), log (CPM) and p value indicated for each gene as Supplementary file 2b.We have uploaded raw RNA sequencing data of liver macrophages isolated from WT and ob/ob mice in the NCBI database, under the following accession number: PRJNA541224.

The following data sets were generated
  1. 1
    Ob/ob liver macrophage RNA sequencing
    1. Morgantini C
    2. Aouadi M
    (2019)
    NCBI BioProject, PRJNA541224.
The following previously published data sets were used
  1. 1

Additional files

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https://cdn.elifesciences.org/articles/47990/elife-47990-supp-v1.zip

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