Cell Biology

Latest articles

1. 1. Cell Biology
   2. Developmental Biology

   Androglobin, a chimeric mammalian globin, is required for male fertility

   Anna Keppner et al.

   Androglobin, a newly identified mammalian globin with a unique modular structure including a protease and calmodulin binding IQ domain within a circularly permuted globin domain, is implicated in murine spermatogenesis.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Visualizing molecules of functional human profilin

   Morgan L Pimm et al.

   Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
3. 1. Cell Biology

   Adaptor linked K63 di-Ubiquitin activates Nedd4/Rsp5 E3 ligase

   Lu Zhu et al.
4. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

   Ritvija Agrawal et al.

   KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.
5. 1. Cell Biology
   2. Developmental Biology

   Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2

   Juan Lu et al.

   When challenged by energetic stresses triggered by hypoxia and ATP inhibition, plasma membrane PI4P and PIP2 in cells undergo dramatic turnovers that have profound impact on many cellular processes including electrostatic PM targeting of numerous polybasic proteins.
6. 1. Cell Biology
   2. Medicine

   SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients

   Eric N Jimenez-Vazquez et al.

   Important mechanistic details on Duchenne Muscular Dystrophy arrhythmogenesis are revealed, providing a crucial lead for investigators interested in developing therapeutic solutions for this deadly disease.
7. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

   Tsuyoshi Imasaki et al.

   CAMSAP2 co-condensates with αβ-tubulin to induce microtubule nucleation and growth, serving as a microtubule-organizing centre for non-centrosomal microtubules.
8. 1. Cell Biology
   2. Developmental Biology

   TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

   Katelyn J Hoff et al.

   The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.
9. 1. Cell Biology

   Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

   Yang Zhang et al.

   A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
10. 1. Cancer Biology
    2. Cell Biology

    Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

    Johnny M Tkach et al.

    Genome-wide CRISPR screens in human cells identifies a role for TRIM37 in growth arrest after chemical inhibition of PLK4.