Cell Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

   Rania Elsabrouty et al.

   Type 1 polyisoprenoid diphosphate phosphatase (PDP1) contributes to interconversion of isoprenols and isoprenylpyrophosphates, balancing the sterol and nonsterol branches of the mevalonate pathway by regulating ERAD of HMG CoA reductase and ER-to-Golgi transport of UBIAD1.
2. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

   Yong Fu et al.
3. 1. Cell Biology

   Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes

   Michelina Kierzek et al.
4. 1. Cell Biology

   Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

   Evgeniya Trofimenko et al.

   Cationic cell-penetrating peptides (CPPs) enter cells through ~2 (–5)-nm-wide water pores induced by the strong negative plasma membrane potential that CPPs and the activity of potassium channels generate.
5. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

   Chet Huan Oon, Kenneth E Prehoda

   Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.
6. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

   Anirban Roy et al.

   The IRE1/XBP1 signaling in myofibers is essential for robust skeletal muscle regeneration in response to injury.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

   Aixin Song et al.

   Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.
8. 1. Cell Biology
   2. Neuroscience

   Ca²⁺/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation

   Domenica Ippolito et al.

   Ca²⁺-dependent nuclear entry of Ca²⁺/calmodulin-dependent protein kinase-1 in sensory neurons, taking place with a relatively slow kinetics, contributes to couple long-lasting sensory stimulations with signaling in the nucleus over a timescale relevant for sensory history-dependent plasticity.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Disentangling bias between G_q, GRK2, and arrestin3 recruitment to the M₃ muscarinic acetylcholine receptor

   Anja Floeser et al.

   Ligand-specific-induced conformations of M₃ muscarinic receptors reveal similar requirements for G protein-coupled receptor kinase 2 and G_q protein binding, whereas arrestin3 binding is mediated by distinct receptor conformations.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface

    Martin Houlard et al.