Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Decisions are made by journal editors who are active researchers in cell biology.

Latest articles

    1. Biochemistry
    2. Cell Biology

    Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

    Paolo Grumati et al.
    Full length RTN3 homodimerization mediates ER tubules fragmentation and their subsequent delivery to lysosome.
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    1. Biophysics and Structural Biology
    2. Cell Biology

    Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips

    Jonathan W Driver et al.
    The protofilaments that curl outward from a disassembling microtubule tip carry a large amount of strain energy and they can drive movement with an efficiency similar to conventional motor proteins.
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    1. Cell Biology

    The human cytoplasmic dynein interactome reveals novel activators of motility

    Willam B Redwine et al.
    1. Cell Biology

    ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins

    Lu Zhu et al.
    The lysosome membrane is a new functional location for the ESCRTs in yeast.
    Research Article Updated
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    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan et al.
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    Research Article
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Organ sculpting by patterned extracellular matrix stiffness

    Justin Crest et al.
    Direct measurement of finely patterned mechanical properties in a native basement membrane demonstrate how force asymmetries arising from this extracellular matrix, rather than from cells, can precisely sculpt a tissue.
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    1. Cell Biology

    The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

    Wenbao Hu et al.
    XIAP/TRIP-Br1-mediated degradation of multiple adenylyl cyclase isoforms is a previously unrecognised general mechanism for controlling adenylyl cyclase expression and the homeostasis of cAMP signalling.
    Research Article Updated
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Highlights

    1. Cell Biology

    Mitochondrial flashes and ATP

    Helena M Viola, Livia C Hool