Cell Biology

Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Learn more about what we publish and sign up for the latest content.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Developmental Biology

    Androglobin, a chimeric mammalian globin, is required for male fertility

    Anna Keppner et al.
    Androglobin, a newly identified mammalian globin with a unique modular structure including a protease and calmodulin binding IQ domain within a circularly permuted globin domain, is implicated in murine spermatogenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Visualizing molecules of functional human profilin

    Morgan L Pimm et al.
    Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

    Ritvija Agrawal et al.
    KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.
    1. Cell Biology
    2. Developmental Biology

    Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2

    Juan Lu et al.
    When challenged by energetic stresses triggered by hypoxia and ATP inhibition, plasma membrane PI4P and PIP2 in cells undergo dramatic turnovers that have profound impact on many cellular processes including electrostatic PM targeting of numerous polybasic proteins.
    1. Cell Biology
    2. Medicine

    SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients

    Eric N Jimenez-Vazquez et al.
    Important mechanistic details on Duchenne Muscular Dystrophy arrhythmogenesis are revealed, providing a crucial lead for investigators interested in developing therapeutic solutions for this deadly disease.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

    Tsuyoshi Imasaki et al.
    CAMSAP2 co-condensates with αβ-tubulin to induce microtubule nucleation and growth, serving as a microtubule-organizing centre for non-centrosomal microtubules.
    1. Cell Biology
    2. Developmental Biology

    TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

    Katelyn J Hoff et al.
    The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.
    1. Cell Biology

    Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

    Yang Zhang et al.
    A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
    1. Cancer Biology
    2. Cell Biology

    Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

    Johnny M Tkach et al.
    Genome-wide CRISPR screens in human cells identifies a role for TRIM37 in growth arrest after chemical inhibition of PLK4.

Senior editors

  1. Anna Akhmanova
    Utrecht University, Netherlands
  2. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  3. Jonathan A Cooper
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, United States
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