Cell Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

   Mikel Garcia-Marcos

   Heterotrimeric G-proteins can be switched on not only by G-protein-coupled receptors but also by cytoplasmic proteins, resulting in different signaling mechanisms in cells depending on the specific type of activator.
2. 1. Cell Biology
   2. Developmental Biology

   The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

   Patrick Morley Willoughby et al.

   Rab25a and Rab25b mutant embryos exhibit epithelial spreading delays during morphogenesis and are characterized by cytokinesis defects leading to cell fusions, heterogeneous epithelial cell sizes, and reduced cortical actomyosin contractility.
3. 1. Cell Biology
   2. Computational and Systems Biology

   Artistoo, a library to build, share, and explore simulations of cells and tissues in the web browser

   Inge M N Wortel, Johannes Textor
4. 1. Cell Biology
   2. Medicine

   Augmenter of Liver Regeneration regulates cellular iron homeostatis by modulating mitochondrial transport of ATP-binding cassette B8

   Hsiang-Chun Chang et al.
5. 1. Cell Biology

   Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

   Nicole R Gould et al.

   Mechanical loading and the bone anabolic action of parathyroid hormone result in rapid, lysosomal degradation of sclerostin protein, revealing physiologically important post-translational control of this critical regulator of bone formation.
6. 1. Cell Biology
   2. Computational and Systems Biology

   CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning

   Ryan Conrad, Kedar Narayan

   'Cellular Electron Microscopy 500,000 images' (CEM500K) is a highly heterogeneous, information-rich, non-redundant, unlabeled EM dataset curated to pre-train DL algorithms for better model generalization on EM segmentation tasks.
7. 1. Cell Biology

   Glucose restriction drives spatial reorganization of mevalonate metabolism

   Sean M Rogers et al.
8. 1. Cell Biology
   2. Neuroscience

   Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations

   Mroj Alassaf, Mary C Halloran

   An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.
9. 1. Cell Biology
   2. Developmental Biology

   A polarity pathway for exocyst-dependent intracellular tube extension

   Joshua Abrams, Jeremy Nance

   Lumen extension in intracellular tubes relies on a molecular pathway involving Rho GTPase signaling, cell polarity, and vesicle-tethering proteins.
10. 1. Cell Biology
    2. Computational and Systems Biology

    Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

    Rosemary Yu et al.

    Global gene expression control mechanisms are modeled using a large dataset consisting of absolute-quantitative proteomics, transcriptomics, and partial metabolomics of Saccharomyces cerevisiae at a wide range of growth conditions.