Cell Biology

Latest articles

1. 1. Cell Biology
   2. Neuroscience

   Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

   Ge Gao, Shuyu Guo ... Gang Peng

   Cholesterol plays an essential role in hair bundles, and Kiaa1024L/Minar2 regulates cholesterol distribution and homeostasis to ensure normal hearing.
2. 1. Cell Biology
   2. Medicine

   Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo

   Sharon Elliot, Paola Catanuto ... Marilyn K Glassberg

   A systemic feature of idiopathic pulmonary fibrosis whereby urine-derived exosomes contain pro-fibrotic microRNAs and interfere with response to tissue injury.
3. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections

   Johannes Elferich, Giulia Schiroli ... Nikolaus Grigorieff

   Cryo-electron microscopy can be used to detect biomolecules in entire 100- to 250-nm-thick cell slices when using a method to collect montages that prevents radiation damage in areas that have not been imaged yet.
4. 1. Cell Biology
   2. Genetics and Genomics

   Unleashing a novel function of Endonuclease G in mitochondrial genome instability

   Sumedha Dahal, Humaira Siddiqua ... Sathees C Raghavan

   A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.
5. 1. Cell Biology

   Insulin sensitivity is preserved in mice made obese by feeding a high starch diet

   Amanda E Brandon, Lewin Small ... Gregory J Cooney

   Mice made obese by feeding a high starch diet do not develop insulin resistance like mice made similarly obese by a high fat diet and this is associated with differences in specific bioactive ceramide species in liver and muscle tissue.
6. 1. Cell Biology

   An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

   Tricia T Nguyen, Gia K Voeltz
7. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

   Martina Oravcová, Minghua Nie ... Michael N Boddy

   SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.
8. 1. Cell Biology
   2. Neuroscience

   Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling

   Damien Jullié, Camila Benitez ... Mark von Zastrow

   Quantitative imaging of neurons reveals how opioid agonists produce long-term functional tolerance at presynaptic terminals through rapid internalization of receptors from the axonal surface.
9. 1. Cell Biology

   A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b

   Shunsuke Saito, Tokiro Ishikawa ... Kazutoshi Mori

   When non-glycosylated, Seipin, which spans the endoplasmic reticulum (ER) membrane twice, forms aggregates in an oligomerization-dependent manner, distorts the shape of the ER, and incorporates SERCA2b via direct interaction, inactivation of which results in induction of ER stress and apoptosis.
10. 1. Cell Biology
    2. Physics of Living Systems

    Fixation can change the appearance of phase separation in living cells

    Shawn Irgen-Gioro, Shawn Ryohei Yoshida ... Shasha Chong