Cell Biology

Latest articles

1. 1. Cell Biology
   2. Genetics and Genomics

   A trans-eQTL network regulates osteoclast multinucleation and bone mass

   Marie Pereira et al.

   MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
2. 1. Cell Biology

   Miga mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis

   Lingna Xu et al.
3. 1. Cell Biology
   2. Genetics and Genomics

   A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

   Weina Zhang et al.
4. 1. Cell Biology
   2. Developmental Biology

   Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation

   Xiaofei Bai et al.

   Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.
5. 1. Cell Biology

   Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

   Abril Angélica Escamilla-Ayala et al.

   Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
6. 1. Cell Biology

   Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

   Jan N Hansen et al.

   Trafficking of optogenetic tools to primary cilia using nanobodies allows to study cAMP signaling with spatial and temporal resolution independent of the cell body.
7. 1. Cell Biology
   2. Physics of Living Systems

   The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

   Akanksha Thawani et al.

   Four αβ-tubulin dimers associate laterally on γ-TuRC to define the rate-limiting transition state for microtubule nucleation.
8. 1. Cell Biology

   A microscopy-based kinetic analysis of yeast vacuolar protein sorting

   Jason C Casler, Benjamin S Glick

   In yeast, a fluorescent vacuolar cargo departs from Golgi cisternae early in the TGN stage of maturation, and traffic from prevacuolar endosomes to the vacuole apparently involves a kiss-and-run mechanism.
9. 1. Cell Biology
   2. Developmental Biology

   Dynamic control of adipose tissue development and adult tissue homeostasis by platelet-derived growth factor receptor alpha

   Sunhye Shin et al.

   Combined fate mapping and genetic deletion studies reveal that PDGFRα+ cells and PDGFRα gene itself are required for adipose tissue development but not for adult tissue homeostasis.
10. 1. Cell Biology

    G protein-regulated endocytic trafficking of adenylyl cyclase type 9

    André M Lazar et al.

    An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.