Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Decisions are made by journal editors who are active researchers in cell biology.

Latest articles

    1. Biochemistry
    2. Cell Biology

    Affimers proteins are versatile and renewable affinity reagents

    Christian Tiede et al.
    The Affimer technology represents renewable binding reagents for molecular biology, which provides research scientists and industry with an alternative to the recently criticised use of animal-produced antibodies.
    Tools and Resources
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

    Pierluigi Scerbo et al.
    Degradation and asymmetric inheritance during cell division of a core pluripotency regulator contributes to lineage commitment in the early Xenopus embryo.
    Research Article
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Organ sculpting by patterned extracellular matrix stiffness

    Justin Crest et al.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

    Max Werth et al.
    A combination of genetic and molecular assays revealed that transcription factor Tfcp2l1 provides the basis for cell patterning and physiologic coordination in kidney collecting ducts.
    Research Article Updated
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    1. Cell Biology

    Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

    Nicolas Talarek et al.
    Inhibition of phosphatases by kinases develops Whi5 phosphorylation and cell cycle function in low cyclin-dependent kinase activity.
    Research Article Updated
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    1. Cell Biology
    2. Genes and Chromosomes

    Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

    Takahiko Akematsu et al.
    The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    Research Article Updated
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    1. Cancer Biology
    2. Cell Biology

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Charles DeRossi et al.
    1. Cell Biology
    2. Neuroscience

    Enhanced FIB-SEM systems for large-volume 3D imaging

    C Shan Xu et al
    Enabling complete neuronal circuit reconstruction and whole-cell imaging of eukaryotes at less than 10 nm isotropic resolution.
    Tools and Resources Updated
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

    Netra Pal Meena, Alan R Kimmel
    Eukaryotic chemotaxis to live bacteria was quantified at a high throughput level, for the first time, and mechanistically examined for the interrelationship between chemotaxis and phagocytosis.
    Research Article Updated
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Highlights

    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg