Cell Biology

Latest articles

1. 1. Cell Biology
   2. Physics of Living Systems

   Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

   Matthew Akamatsu et al.

   An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

   Mable Lam et al.

   Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

   Miriam Stoeber et al.

   Chemically distinct opioid ligands promote selective protein recruitment by opioid receptors in intact cells.
4. 1. Cell Biology

   EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD

   Ginto George et al.

   EDEM2 containing mannosidase homology domain functions as an initiator of endoplasmic reticulum-associated degradation of misfolded glycoproteins by conversion of Man₉GlcNAc₂ to Man₈GlcNAc₂, only when complexed with TXNDC11 containing thioredoxin-like domains.
5. 1. Cell Biology
   2. Neuroscience

   Large-scale cell-type-specific imaging of protein synthesis in a vertebrate brain

   Or David Shahar, Erin Margaret Schuman

   The development of a transgenic zebrafish allows for cell-type-specific labeling of neuronal protein synthesis, enabling brain-wide visualization and quantification of protein synthesis and demonstrating region-specific increases following elevated brain activity.
6. 1. Cell Biology

   Control of cell death/survival balance by the MET dependence receptor

   Leslie Duplaquet et al.

   MET acts as a dependence receptor in vivo by promoting hepatocyte apoptosis, a response induced by a caspase generated fragment able to favor calcium exchange between endoplasmic reticulum and mitochondria.
7. 1. Cancer Biology
   2. Cell Biology

   Junction Mapper is a novel computer vision tool to decipher cell–cell contact phenotypes

   Helena Brezovjakova et al.

   Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
8. 1. Cell Biology
   2. Ecology

   Ubiquitous macropinocytosis in anthozoans

   Philippe Ganot et al.

   Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
9. 1. Cell Biology

   Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

   Chia-An Yen et al.

   Loss of FAD stemming from cell autonomous defects in mitochondrial proline catabolism impairs sperm quality male reproductive advantage in C. elegans.
10. 1. Cell Biology
    2. Developmental Biology

    Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

    Claudia Prahst et al.