Cell Biology

Latest articles

1. 1. Cell Biology
   2. Physics of Living Systems

   Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

   Andrea Serra-Marques et al.

   The function and distribution of kinesin motors on exocytotic vesicles is dissected and visualized through a combination of gene knockout experiments, high-resolution microscopy and advanced data analysis.
2. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Sperm: The secrets of success

   Kayla M Komondor, Anne E Carlson

   Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level.
3. 1. Cell Biology

   Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

   Chanjae Lee et al.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks

   Connor J Balzer et al.

   An activator of branching nucleation by Arp2/3 complex directly synergizes with an activator of linear filament nucleation to initiate assembly of actin networks that drive endocytosis.
5. 1. Cell Biology

   A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics

   Etai Sapoznik et al.

   A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.
6. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

   Lukas Ded et al.

   Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.
7. 1. Cell Biology
   2. Physics of Living Systems

   A physical mechanism of TANGO1-mediated bulky cargo export

   Ishier Raote et al.

   TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
8. 1. Cell Biology
   2. Developmental Biology

   Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

   Yan Xiong et al.

   Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
9. 1. Cell Biology
   2. Medicine

   Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

   LouJin Song et al.

   Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
10. 1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1⁺ epicardial cells

    Na Li et al.

    Brain natriuretic peptide supplementation can increase cardiac neovascularization in infarcted hearts by stimulating endogenous endothelial cell proliferation and proliferation of precursor cells, which will differentiate into endothelial cells.