Cell Biology

Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Learn more about what we publish and sign up for the latest content.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Neuroscience

    Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

    Ge Gao, Shuyu Guo ... Gang Peng
    Cholesterol plays an essential role in hair bundles, and Kiaa1024L/Minar2 regulates cholesterol distribution and homeostasis to ensure normal hearing.
    1. Cell Biology
    2. Medicine

    Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo

    Sharon Elliot, Paola Catanuto ... Marilyn K Glassberg
    A systemic feature of idiopathic pulmonary fibrosis whereby urine-derived exosomes contain pro-fibrotic microRNAs and interfere with response to tissue injury.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections

    Johannes Elferich, Giulia Schiroli ... Nikolaus Grigorieff
    Cryo-electron microscopy can be used to detect biomolecules in entire 100- to 250-nm-thick cell slices when using a method to collect montages that prevents radiation damage in areas that have not been imaged yet.
    1. Cell Biology
    2. Genetics and Genomics

    Unleashing a novel function of Endonuclease G in mitochondrial genome instability

    Sumedha Dahal, Humaira Siddiqua ... Sathees C Raghavan
    A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.
    1. Cell Biology

    Insulin sensitivity is preserved in mice made obese by feeding a high starch diet

    Amanda E Brandon, Lewin Small ... Gregory J Cooney
    Mice made obese by feeding a high starch diet do not develop insulin resistance like mice made similarly obese by a high fat diet and this is associated with differences in specific bioactive ceramide species in liver and muscle tissue.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

    Martina Oravcová, Minghua Nie ... Michael N Boddy
    SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.
    1. Cell Biology
    2. Neuroscience

    Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling

    Damien Jullié, Camila Benitez ... Mark von Zastrow
    Quantitative imaging of neurons reveals how opioid agonists produce long-term functional tolerance at presynaptic terminals through rapid internalization of receptors from the axonal surface.
    1. Cell Biology

    A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b

    Shunsuke Saito, Tokiro Ishikawa ... Kazutoshi Mori
    When non-glycosylated, Seipin, which spans the endoplasmic reticulum (ER) membrane twice, forms aggregates in an oligomerization-dependent manner, distorts the shape of the ER, and incorporates SERCA2b via direct interaction, inactivation of which results in induction of ER stress and apoptosis.
    1. Cell Biology
    2. Physics of Living Systems

    Fixation can change the appearance of phase separation in living cells

    Shawn Irgen-Gioro, Shawn Ryohei Yoshida ... Shasha Chong

Senior editors

  1. Anna Akhmanova
    Utrecht University, Netherlands
  2. Jonathan A Cooper
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, United States
  3. Vivek Malhotra
    The Barcelona Institute of Science and Technology, Spain
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