Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Decisions are made by journal editors who are active researchers in cell biology.

Latest articles

    1. Cell Biology
    2. Genes and Chromosomes

    Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

    Takahiko Akematsu et al.
    The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    Research Article Updated
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    1. Cancer Biology
    2. Cell Biology

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Charles DeRossi et al.
    1. Cell Biology
    2. Neuroscience

    Enhanced FIB-SEM systems for large-volume 3D imaging

    C Shan Xu et al
    Enabling complete neuronal circuit reconstruction and whole-cell imaging of eukaryotes at less than 10 nm isotropic resolution.
    Tools and Resources Updated
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

    Netra Pal Meena, Alan R Kimmel
    Eukaryotic chemotaxis to live bacteria was quantified at a high throughput level, for the first time, and mechanistically examined for the interrelationship between chemotaxis and phagocytosis.
    Research Article Updated
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    1. Cell Biology
    2. Genes and Chromosomes

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan et al
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
    Research Article Updated
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    1. Cell Biology
    2. Computational and Systems Biology

    Functional mapping of yeast genomes by saturated transposition

    Agnès H Michel et al
    A new method maps functional and structural features of yeast genomes with unprecedented ease and throughput, which allows identification of protein domains at the genome scale.
    Tools and Resources Updated
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Highlights

    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg