Cell Biology

Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Learn more about what we publish and sign up for the latest content.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Immunology and Inflammation

    A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

    Jia C Wang et al.
    B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.
    1. Cell Biology

    CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

    Désirée Schatton et al.
    CLUH links growth signaling pathways and mitochondrial metabolism with cell cycle progression by regulating astrin-1 synthesis and stability.
    1. Cell Biology

    Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

    Robert J Tower et al.
    Metabolic supplementation attenuates age-dependent declines in regeneration.
    1. Cell Biology

    Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

    Wenyang Li et al.
    A high-throughput small molecule screen defined compounds that inactivate primary human hepatic stellate cells (HSCs) and led to the identification of nanchangmycin, which regulates intracellular Ca2+ levels and the activity of multiple kinases to control HSC fibrotic activity.
    1. Cell Biology

    Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion

    Dillon Jevon et al.
    The essential role of focal adhesion kinase in locally regulating insulin secretion and calcium responses in pancreatic beta cells is identified through the use of the pancreatic slice technique.
    1. Cell Biology

    C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

    Saskia-Larissa Jauch-Speer et al.
    A genome-wide CRISPR/Cas9 knockout screening approach identified C/EBPδ as transcriptional regulator of the alarmins S100A8 and S100A9 during differentiation of monocytes and inflammatory processes in vivo.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    Haikel Dridi et al.
    The Ryanodine receptor type 1 calcium channels play a critical role in age-related muscle function loss.
    1. Cell Biology
    2. Physics of Living Systems

    Zebrafish airinemes optimize their shape between ballistic and diffusive search

    Sohyeon Park et al.
    Mathematical characterization of the shape of cellular protrusions that form cell–cell contacts in tissues reveals the parameters required for optimizing biological functional objectives, like maximizing cell–cell contact and communicating directional information.
    1. Cell Biology
    2. Neuroscience

    The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus

    Natasha M Puri et al.
    Dopamine D1 receptor signaling from the Golgi apparatus in murine striatal medium spiny neurons is regulated by monoamine transporter OCT2.

Senior editors

  1. Anna Akhmanova
    Utrecht University, Netherlands
  2. Marianne E Bronner
    Marianne E Bronner
    California Institute of Technology, United States
  3. Suzanne R Pfeffer
    Stanford University School of Medicine, United States
  4. See more editors