Cell Biology

Cell Biology

eLife publishes research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Learn more about what we publish and sign up for the latest content.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

    Rania Elsabrouty et al.
    Type 1 polyisoprenoid diphosphate phosphatase (PDP1) contributes to interconversion of isoprenols and isoprenylpyrophosphates, balancing the sterol and nonsterol branches of the mevalonate pathway by regulating ERAD of HMG CoA reductase and ER-to-Golgi transport of UBIAD1.
    1. Cell Biology

    Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

    Evgeniya Trofimenko et al.
    Cationic cell-penetrating peptides (CPPs) enter cells through ~2 (–5)-nm-wide water pores induced by the strong negative plasma membrane potential that CPPs and the activity of potassium channels generate.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

    Chet Huan Oon, Kenneth E Prehoda
    Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

    Anirban Roy et al.
    The IRE1/XBP1 signaling in myofibers is essential for robust skeletal muscle regeneration in response to injury.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

    Aixin Song et al.
    Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.
    1. Cell Biology
    2. Neuroscience

    Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation

    Domenica Ippolito et al.
    Ca2+-dependent nuclear entry of Ca2+/calmodulin-dependent protein kinase-1 in sensory neurons, taking place with a relatively slow kinetics, contributes to couple long-lasting sensory stimulations with signaling in the nucleus over a timescale relevant for sensory history-dependent plasticity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

    Anja Floeser et al.
    Ligand-specific-induced conformations of M3 muscarinic receptors reveal similar requirements for G protein-coupled receptor kinase 2 and Gq protein binding, whereas arrestin3 binding is mediated by distinct receptor conformations.

Senior editors

  1. Anna Akhmanova
    Utrecht University, Netherlands
  2. Jonathan A Cooper
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, United States
  3. Erica Golemis
    Fox Chase Cancer Center, United States
  4. See more editors