Cell Biology

Latest articles

1. 1. Cell Biology
   2. Plant Biology

   Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens

   Elena Kozgunova et al.

   Lagging chromosomes in anaphase inhibits cytokinesis in plant cells.
2. 1. Cell Biology

   Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

   Peipei Zhang et al.

   OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
3. 1. Cell Biology
   2. Genetics and Genomics

   Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

   Martin Wegner et al.

   Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
4. 1. Cell Biology
   2. Developmental Biology

   Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network

   Torey R Arnold et al.

   In epithelial cells, anillin organizes the medial-apical actomyosin cortex into a contractile load-bearing structure and increases tissue-level stiffness.
5. 1. Cell Biology
   2. Neuroscience

   The SNAP-25 linker supports fusion intermediates by local lipid interactions

   Ahmed Shaaban et al.

   The SNAP-25 linker acts as a functional component of SNARE complexes, initially facilitating SNARE interactions and later promoting fusion triggering and pore evolution by local membrane contacts.
6. 1. Cell Biology

   Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans

   Kerstin Klinkert et al.

   Experiments reveal mechanisms through which Caenorhabditis elegans zygotes depleted of Aurora A or lacking centrosomes spontaneously establish two posterior PAR-2 domains, one at each pole, in a curvature-dependent manner.
7. 1. Cell Biology

   Quantitative regulation of the dynamic steady state of actin networks

   Angelika Manhart et al.

   Cells are able to control the actin network length and steering by adjusting geometric, structural, or biochemical parameters such as ADF/Cofilin and actin concentrations, and network width.
8. 1. Cell Biology

   Inadequate BiP availability defines endoplasmic reticulum stress

   Milena Vitale et al.

   The extent of (proteotoxic) endoplasmic reticulum stress, and the ensuing unfolded protein response activation, are commensurate with the extent of the chaperone BiP being sequestered by its client proteins.
9. 1. Cell Biology

   The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

   Rolf M Schmidt et al.

   Endoplasmic reticulum stress in yeast activates not only the UPR but also Rpn4, promoting the clearance of misfolded proteins from the cytosol as part of a modular cross-compartment stress response.
10. 1. Cancer Biology
    2. Cell Biology

    Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

    Qian Liu et al.

    The pro-apoptotic BH3-protein Bim contains two distinct binding sites for anti-apoptotic proteins that together confer resistance of Bim/Bcl-2 and Bim/Bcl-XL complexes to BH3-mimetic drugs under development for use in humans.