Cell Biology

Latest articles

1. 1. Cell Biology

   The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

   Eutteum Jeong et al.

   Disruption of TFEB and TFE3 results in diminished p53 signaling capacity and altered cell cycle regulation under genotoxic stress conditions.
2. 1. Cell Biology

   The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

   Sam A Menzies et al.

   CRISPR/Cas9 genome-wide screens using sterol-sensitive endogenous HMG-CoA reductase (HMGCR) reporter identify the sterol-responsive RNF145 and gp78 as independently responsible for sterol-accelerated degradation of HMGCR, the rate-limiting enzyme of cholesterol biosynthesis.
3. 1. Cell Biology

   Muscle specific stress fibers give rise to sarcomeres in cardiomyocytes

   Aidan M Fenix et al.
4. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

   Junyi Jiao et al.
5. 1. Cell Biology

   Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation

   Claudia Pellacani et al.

   Extensive cytological and biochemical analyses show that the conserved Sf3A2 and Prp31 splicing factors bind microtubules and the Ndc80 complex, playing direct mitotic functions in both Drosophila and human mitosis.
6. 1. Cell Biology

   Glucose intake hampers PKA-regulated HSP90 chaperone activity

   Yu-Chen Chen et al.

   Food overconsumption impairs cellular protein folding through a novel aging-related signaling pathway.
7. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein

   Xiao-Man Liu et al.

   The core autophagy protein Atg8 plays non-autophagy roles through binding to an integral membrane protein Hfl1, which harbors an unusual Atg8-interacting motif.
8. 1. Cell Biology

   Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2

   Mario Ruiz et al.

   Inhibition of C. elegans FLD-1 or Human TLCD1/2 prevents saturated fat lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.
9. 1. Cell Biology
   2. Human Biology and Medicine

   Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

   Martina Rudnicki et al.

   Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.
10. 1. Cell Biology
    2. Neuroscience

    The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

    Lorna Moll et al.

    By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.