Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum

Abstract
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Abstract

Rhythmic events recruit neuronal activity in the basal ganglia and cerebellum, but their roles remain elusive. In monkeys attempting to detect a single omission of isochronous visual stimulus, we found that neurons in the caudate nucleus showed increased activity for each stimulus in sequence, while those in the cerebellar dentate nucleus showed decreased activity. Firing modulation in the majority of caudate neurons and all cerebellar neurons was proportional to the stimulus interval, but a quarter of caudate neurons displayed a clear duration tuning. Furthermore, the time course of population activity in the cerebellum well predicted stimulus timing, whereas that in the caudate reflected stochastic variation of response latency. Electrical stimulation to the respective recording sites confirmed a causal role in the detection of stimulus omission. These results suggest that striatal neurons might represent periodic response preparation while cerebellar nuclear neurons may play a role in temporal prediction of periodic events.

Data availability

We now upload data files (in Matlab's MAT format) containing numerical data sufficient to reconstruct each main figure.

The following previously published data sets were used

(2013) Temporally specific sensory signals for the detection of stimulus omission in the primate deep cerebellar nuclei.
doi:10.1523/JNEUROSCI.1698-13.2013.

http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=24068812

Article and author information

Author details

Masashi Kameda

Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan

Competing interests
The authors declare that no competing interests exist.
Shogo Ohmae

Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0003-1726-4961
Masaki Tanaka

Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan

For correspondence
masaki@med.hokudai.ac.jp

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0002-6177-1314

Funding

Ministry of Education, Culture, Sports, Science, and Technology (17H03539)

Masaki Tanaka

Takeda Science Foundation

Masaki Tanaka

Japan Society for the Promotion of Science

Masashi Kameda

Ministry of Education, Culture, Sports, Science, and Technology (18H04928)

Masaki Tanaka

Ministry of Education, Culture, Sports, Science, and Technology (18H05523)

Masaki Tanaka

Ministry of Education, Culture, Sports, Science, and Technology (18J20197)

Masaki Tanaka

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All experimental protocols were evaluated and approved by the Hokkaido University Animal Care and Use Committee (#18-0003).

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.