Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum
Abstract
Rhythmic events recruit neuronal activity in the basal ganglia and cerebellum, but their roles remain elusive. In monkeys attempting to detect a single omission of isochronous visual stimulus, we found that neurons in the caudate nucleus showed increased activity for each stimulus in sequence, while those in the cerebellar dentate nucleus showed decreased activity. Firing modulation in the majority of caudate neurons and all cerebellar neurons was proportional to the stimulus interval, but a quarter of caudate neurons displayed a clear duration tuning. Furthermore, the time course of population activity in the cerebellum well predicted stimulus timing, whereas that in the caudate reflected stochastic variation of response latency. Electrical stimulation to the respective recording sites confirmed a causal role in the detection of stimulus omission. These results suggest that striatal neurons might represent periodic response preparation while cerebellar nuclear neurons may play a role in temporal prediction of periodic events.
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Author details
Funding
Ministry of Education, Culture, Sports, Science, and Technology (17H03539)
- Masaki Tanaka
Takeda Science Foundation
- Masaki Tanaka
Japan Society for the Promotion of Science
- Masashi Kameda
Ministry of Education, Culture, Sports, Science, and Technology (18H04928)
- Masaki Tanaka
Ministry of Education, Culture, Sports, Science, and Technology (18H05523)
- Masaki Tanaka
Ministry of Education, Culture, Sports, Science, and Technology (18J20197)
- Masaki Tanaka
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Jennifer L Raymond, Stanford School of Medicine, United States
Ethics
Animal experimentation: All experimental protocols were evaluated and approved by the Hokkaido University Animal Care and Use Committee (#18-0003).
Version history
- Received: May 23, 2019
- Accepted: September 5, 2019
- Accepted Manuscript published: September 6, 2019 (version 1)
- Version of Record published: September 17, 2019 (version 2)
Copyright
© 2019, Kameda et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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