Can education be personalised using pupils’ genetic data?
- MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom
- Population Health Sciences, Bristol Medical School, University of Bristol, United Kingdom
Figures
Figure 1
Variance in age 7 educational achievement explained by the polygenic scores.
(A) Variance explained in age 7 educational achievement by the polygenic scores while controlling for pupil characteristics and social factors. (B) Additional variance explained by the polygenic …
Figure 2
Variance in age 16 achievement explained by the polygenic scores.
(A) Variance explained in age 16 educational achievement by the polygenic scores while controlling for pupil characteristics and social factors. (B) Additional variance explained by the polygenic …
Figure 3 with 1 supplement
Distributions of polygenic scores between ‘high achievers’ and all other pupils.
(A) Polygenic score distributions for the GWAS significant polygenic score. (B) Polygenic score distributions for the all SNP polygenic score. High achievers defined as pupils with age 16 …
Figure 3—figure supplement 1
Distributions of prior achievement between ‘high achievers’ at age 16 and all other pupils.
(A) Prior achievement at age 7. (B) Prior achievement at age 11. (C) Prior achievement at age 14. Educational achievement (EA) measured using fine graded point scores from educational exams taken at …
Figure 4 with 1 supplement
Correlation between realised and genetically predicted achievement.
Educational achievement measured using fine graded point scores from educational exams at age 16. Predicted achievement at age 16 generated from a polygenic score built using all education …
Figure 4—figure supplement 1
Independent scatter plots showing correlation between realised achievement at age 16 and achievement predicted from genotypic and phenotypic variables with top 10% of predicted achievers highlighted in green.
Educational achievement measured using fine graded point scores from educational exams. Genetically predicted achievement at age 16 generated from a polygenic score built using all education …
Figure 5 with 1 supplement
ROC curve for being a high achieving student (defined as the top 10% of pupils) at age 7.
High achievers defined as pupils with age 16 educational exam scores in the top 10% of the sample. Parental educational attainment (EA) was measured as average years of completed education. Parental …
Figure 5—figure supplement 1
Independent ROC curves for deciled measures of polygenic scores, parental education and parental socioeconomic position predicting high achieving students at age 7 defined at different thresholds (e.g. top 10%).
Parents educational attainment (EA) measured as years of completed education. Parents socioeconomic position (SEP) measured as highest parental score on the CAMSIS social class scale. Polygenic …
Figure 6 with 2 supplements
ROC curves for being a high achievement student (pupils with age 16 educational exam scores in the top 10% of the sample) at age 16.
(A) Independent ROC curves for deciled measures of prior achievement and polygenic scores (PGS) predicting high educational achievement (EA) at age 16. (B) Independent ROC curves for deciled …
Figure 6—figure supplement 1
ROC curves for deciled measures of polygenic scores predicting high achieving students at age 16 (pupils with age 16 educational exam scores in the top 10% of the sample) conditional on prior attainment and pupil characteristics.
Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (all SNP PGS) from the largest GWAS of educational attainment1. Pupil …
Figure 6—figure supplement 2
Independent ROC curves for deciled measures of prior attainment and polygenic scores predicting high achieving students at age 16 defined at different thresholds (e.g. top 1%).
Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (all SNP PGS) from the largest GWAS of educational attainment1. All PGS analyses …
Tables
Table 1
Correlation coefficients between educational achievement at ages 7 and 16 and the genotypic and social predictors.
Educational achievement measured using fine graded point scores from educational exams at ages 7 and 16. Genotypic predictors measured using two polygenic scores (PGS) built using only genome-wide …
| Achievement age 7 | Achievement 16 | |
|---|---|---|
| GWAS sig PGS | 0.17 | 0.19 |
| All SNP PGS | 0.26 | 0.37 |
| Mothers EA | 0.28 | 0.39 |
| Fathers EA | 0.27 | 0.40 |
| Parents SEP | 0.30 | 0.40 |
Additional files
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Supplementary file 1
Full parameter estimates for all models presented throughout the manuscript.
(A) Variance explained in educational achievement at age 7. Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (All SNP PGS) from the largest GWAS of educational attainment (Lee et al., 2018). FSM, Free School Meals. EFL, English as a Foreign Language. SEN, Special Educational Needs. Eduyears, years of education. SEP, socioeconomic position. (B) Incremental R2 for educational achievement at age 7. Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (All SNP PGS) from the largest GWAS of educational attainment (Lee et al., 2018). FSM, Free School Meals. EFL, English as a Foreign Language. SEN, Special Educational Needs. Eduyears, years of education. SEP, socioeconomic position. (C) Variance explained in educational achievement at age 16. Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (All SNP PGS) from the largest GWAS of educational attainment (Lee et al., 2018). FSM, Free School Meals. EFL, English as a Foreign Language. SEN, Special Educational Needs. EA7, prior educational achievement at age 7. EA11, prior educational achievement at age 11. EA14, prior educational achievement at age 14. Eduyears, years of education. SEP, socioeconomic position. (D) Incremental R2 for educational achievement at age 16. Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (All SNP PGS) from the largest GWAS of educational attainment (Lee et al., 2018). FSM, Free School Meals. EFL, English as a Foreign Language. SEN, Special Educational Needs. EA7, prior educational achievement at age 7. EA11, prior educational achievement at age 11. EA14, prior educational achievement at age 14. (E) Agreement between educational achievement (EA) quantiles and other quantiled measures. Polygenic scores (PGS) built using only genome-wide significant SNPs (GWAS sig PGS) or all education associated SNPs (All SNP PGS) from the largest GWAS of educational attainment (Lee et al., 2018). p values for all tests < 0.001.
- https://cdn.elifesciences.org/articles/49962/elife-49962-supp1-v1.xlsx
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Transparent reporting form
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