Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we investigated the hypothesis that specific modulatory signals shape memory formation into a state that is reconsolidation-resistant. We find that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of stability at the expense of lability in the amygdala of rats. Preventing the NOR-LC from modulating strong fear encoding results in the formation of memories that can undergo reconsolidation within the amygdala and thus are vulnerable to post-reactivation interference. Thus, the memory strength boundary condition on reconsolidation is set at the time of encoding by the action of the NOR-LC.
All data is available via Dryad doi:10.5061/dryad.70rxwdbtq
Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidationDryad Digital Repository, doi:10.5061/dryad.70rxwdbtq.
- Karim Nader
- Karim Nader
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Animal experimentation: All procedures were approved by McGill's Animal Care Committee (Animal Use Protocol #2000-4512) and complied with the Canadian Council on Animal Care guidelines.
- Mihaela D Iordanova, Concordia University, Canada
© 2020, Haubrich et al.
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