Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior

  1. Kazuki Shiotani
  2. Yuta Tanisumi
  3. Koshi Murata
  4. Junya Hirokawa
  5. Yoshio Sakurai
  6. Hiroyuki Manabe  Is a corresponding author
  1. Graduate School of Brain Science, Doshisha University, Japan
  2. Faculty of Medical Sciences, University of Fukui, Japan
  3. Doshisha University, Japan

Abstract

The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors.

Data availability

All data generated or analysed during this study are included in the manuscript and supporting files.Source data files have been provided for Figure 2, 3, 5 and 6.

Article and author information

Author details

  1. Kazuki Shiotani

    Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-5596-5609
  2. Yuta Tanisumi

    Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan
    Competing interests
    The authors declare that no competing interests exist.
  3. Koshi Murata

    Division of Brain Structure and Function, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Competing interests
    The authors declare that no competing interests exist.
  4. Junya Hirokawa

    Graduate School of Brain Science, Graduate School of Brain Science, Doshisha University, Kyotanabe, Japan
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-1238-5713
  5. Yoshio Sakurai

    Graduate School of Brain Science, Doshisha University, Doshisha University, Kyoto, Japan
    Competing interests
    The authors declare that no competing interests exist.
  6. Hiroyuki Manabe

    Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan
    For correspondence
    hmanabe@mail.doshisha.ac.jp
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3910-4849

Funding

Japan Society for the Promotion of Science (Grant-in-Aid for JSPS Fellows 18J21358)

  • Kazuki Shiotani

Japan Society for the Promotion of Science (Grant-in-Aid for Challenging Exploratory Research 16K14557)

  • Hiroyuki Manabe

Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research on Innovative Areas 25135708)

  • Hiroyuki Manabe

Takeda Science Foundation

  • Hiroyuki Manabe

Narishige Neuroscience Research Foundation

  • Hiroyuki Manabe

Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research(A) 16H02061)

  • Yoshio Sakurai

Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research on Innovative Areas 18H05088)

  • Yoshio Sakurai

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: Animal experimentation: Animal experiments were approved and performed in accordance with the guidelines for the care and use of laboratory animals established by the Committee for Animal Care (Permit Number: A15089, A16013, A17007, A18011) of Doshisha University. All efforts were made to minimize animal suffering and the number of animals used.

Reviewing Editor

  1. Naoshige Uchida, Harvard University, United States

Version history

  1. Received: March 26, 2020
  2. Accepted: August 1, 2020
  3. Accepted Manuscript published: August 4, 2020 (version 1)
  4. Version of Record published: August 12, 2020 (version 2)

Copyright

© 2020, Shiotani et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Kazuki Shiotani
  2. Yuta Tanisumi
  3. Koshi Murata
  4. Junya Hirokawa
  5. Yoshio Sakurai
  6. Hiroyuki Manabe
(2020)
Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior
eLife 9:e57268.
https://doi.org/10.7554/eLife.57268

Share this article

https://doi.org/10.7554/eLife.57268

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