Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior
- Graduate School of Brain Science, Doshisha University, Japan
- Faculty of Medical Sciences, University of Fukui, Japan
- Doshisha University, Japan
Abstract
The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files.Source data files have been provided for Figure 2, 3, 5 and 6.
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Author details
Funding
Japan Society for the Promotion of Science (Grant-in-Aid for JSPS Fellows 18J21358)
- Kazuki Shiotani
Japan Society for the Promotion of Science (Grant-in-Aid for Challenging Exploratory Research 16K14557)
- Hiroyuki Manabe
Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research on Innovative Areas 25135708)
- Hiroyuki Manabe
Takeda Science Foundation
- Hiroyuki Manabe
Narishige Neuroscience Research Foundation
- Hiroyuki Manabe
Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research(A) 16H02061)
- Yoshio Sakurai
Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research on Innovative Areas 18H05088)
- Yoshio Sakurai
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: Animal experimentation: Animal experiments were approved and performed in accordance with the guidelines for the care and use of laboratory animals established by the Committee for Animal Care (Permit Number: A15089, A16013, A17007, A18011) of Doshisha University. All efforts were made to minimize animal suffering and the number of animals used.
Copyright
© 2020, Shiotani et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior
eLife 9:e57268.
https://doi.org/10.7554/eLife.57268
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