1. Microbiology and Infectious Disease
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Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

  1. PJ Klasse  Is a corresponding author
  2. John P Moore
  1. Department of Microbiology and Immunology, Weill Cornell Medicine, United States
Review Article
Cite this article as: eLife 2020;9:e57877 doi: 10.7554/eLife.57877
1 table

Tables

Table 1
Passive immunization with convalescent plasma (CP) during SARS-CoV-1 and SARS-CoV-2 infection.
ReferenceVirusAntibody sourceNumber of patientsEfficacySafety

Cheng et al., 2005
SARS-CoV-1CP
160–640 ml
Seropositive titer range:
160–2,560
80 patients with SARSBetter outcome with plasma before than after day 14No immediate adverse effects

Yeh et al., 2005
SARS-CoV-1CP
500 ml
IF IgG titer
>640
3 hospital workers with SARSDrop within 24 hr in viral load from ~ 105 to < 1 RNA copies/mlNo significant side effects

Soo et al., 2004
SARS-CoV-1CP
Ab titers not measured
19 (plasma) vs. 21 (methylprednisolone) SARS patientsFaster release, lower mortality with plasma than comparatorNo immediate adverse effects

Shen et al., 2020
SARS-CoV-2CP 400 ml
Ab binding
>1000
NAb > 40
5 COVID-19 patientsReduced viral load, clinical improvement Release of 3/5None reported

Duan et al., 2020
SARS-CoV-2CP 200 ml
NAb > 640
10 COVID-19 patientsVirus undetectable in 7/10
Varying clinical, laboratory, radiological improvements
No adverse effects observed

Zhang et al., 2020
SARS-CoV-2CP 200–2,400 ml
Ab not measured
4 COVID-19 patientsNegative PCR
Pulmonological improvements
Discharge of 3/4
No adverse effects observed

Ahn et al., 2020
SARS-CoV-2CP 2 × 250 ml
Binding IgG detected by ELISA
2 COVID-19 patientsReduced sputum viral load Radiological and clinical improvementsNo adverse effects observed

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