1. Microbiology and Infectious Disease
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Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

  1. PJ Klasse  Is a corresponding author
  2. John P Moore
  1. Department of Microbiology and Immunology, Weill Cornell Medicine, United States
Review Article
Cite this article as: eLife 2020;9:e57877 doi: 10.7554/eLife.57877
1 table


Table 1
Passive immunization with convalescent plasma (CP) during SARS-CoV-1 and SARS-CoV-2 infection.
ReferenceVirusAntibody sourceNumber of patientsEfficacySafety

Cheng et al., 2005
160–640 ml
Seropositive titer range:
80 patients with SARSBetter outcome with plasma before than after day 14No immediate adverse effects

Yeh et al., 2005
500 ml
IF IgG titer
3 hospital workers with SARSDrop within 24 hr in viral load from ~ 105 to < 1 RNA copies/mlNo significant side effects

Soo et al., 2004
Ab titers not measured
19 (plasma) vs. 21 (methylprednisolone) SARS patientsFaster release, lower mortality with plasma than comparatorNo immediate adverse effects

Shen et al., 2020
SARS-CoV-2CP 400 ml
Ab binding
NAb > 40
5 COVID-19 patientsReduced viral load, clinical improvement Release of 3/5None reported

Duan et al., 2020
SARS-CoV-2CP 200 ml
NAb > 640
10 COVID-19 patientsVirus undetectable in 7/10
Varying clinical, laboratory, radiological improvements
No adverse effects observed

Zhang et al., 2020
SARS-CoV-2CP 200–2,400 ml
Ab not measured
4 COVID-19 patientsNegative PCR
Pulmonological improvements
Discharge of 3/4
No adverse effects observed

Ahn et al., 2020
SARS-CoV-2CP 2 × 250 ml
Binding IgG detected by ELISA
2 COVID-19 patientsReduced sputum viral load Radiological and clinical improvementsNo adverse effects observed

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