Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Immunology and Inflammation

    Variation in the basal immune state and implications for disease

    Aisha Souquette, Paul G Thomas
    An integrative conceptual and mathematical framework of immune variation that includes unique basal profiles associated with differential susceptibility to disease, distinct acute immune signatures associated with disease severity, and how different determinants can lead to individual pathways of illness outcome.
    1. Neuroscience

    Designing optimal behavioral experiments using machine learning

    Simon Valentin, Steven Kleinegesse ... Christopher G Lucas
    Recent advances in Bayesian optimal experimental design have made it possible to improve the efficiency and informativeness of experiments using machine learning, and shed new light on considerations that affect machine learning assisted experimental designs and computational models in general.
    1. Cell Biology

    Location, location, location: Protein kinase nanoclustering for optimised signalling output

    Rachel S Gormal, Ramon Martinez-Marmol ... Frédéric A Meunier
    This article reviews the latest studies that have used super-resolution microscopy and cluster analysis methodologies to study the mechanism of protein kinase signalling hubs and their organisation at nanoscale.
    1. Ecology
    2. Evolutionary Biology

    Sensory collectives in natural systems

    Hannah J Williams, Vivek H Sridhar ... Amanda D Melin
    A synthetic, prospective article considers how the fields of sensory ecology and collective behaviour can combine when considering animal collective movements and interactions, and how these fields can inspire each other to advance understanding of animal behaviour, adaptation and evolution.
    1. Neuroscience

    Circular and unified analysis in network neuroscience

    Mika Rubinov
    Circular analyses of knowledge are a common, serious, but often manageable problem in systems and network neuroscience.
    1. Medicine

    Eleven strategies for making reproducible research and open science training the norm at research institutions

    Friederike E Kohrs, Susann Auer ... Tracey L Weissgerber
    Researchers and administrators can integrate reproducible research and open science practices into daily practice at their research institutions by adapting research assessment criteria and program requirements, offering training, and building communities.
    1. Neuroscience

    Against cortical reorganisation

    Tamar R Makin, John W Krakauer
    A critical re-evaluation of some of the quintessential examples given as evidence for cortical reorganisation argues that, contrary to the prevalent view, any opportunities for functional change in cortical organisation are incremental and constrained by the underlying structural ‘blueprint'.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems genetics approaches for understanding complex traits with relevance for human disease

    Hooman Allayee, Charles R Farber ... Aldons J Lusis
    Systems genetics is a powerful approach that links DNA variation to complex clinical and physiological traits through the integration of intermediate phenotypes, such as RNA, protein, and metabolite levels.
    1. Medicine

    Structural insights into the career path between pre- and postgraduate physician-scientist training programs

    Christopher S Williams, Emily J Gallagher ... Kyu Y Rhee
    Essential advice for trainees when evaluating postgraduate physician scientist training programs.
    1. Developmental Biology
    2. Evolutionary Biology

    Gene expression mapping of the neuroectoderm across phyla – conservation and divergence of early brain anlagen between insects and vertebrates

    Nico Posnien, Vera S Hunnekuhl, Gregor Bucher
    Hypotheses on brain homologies between insects and vertebrates are tested by comparing gene expression patterns from flies and beetles with those from vertebrates at early neuroectoderm stages.