Review Articles

Latest articles

1. 1. Neuroscience

   How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms

   Julia Ruge, Mana R Ehlers ... Tina B Lonsdorf

   Individuals with a history of adverse childhood experiences show blunted response to threat and reward irrespective of sample and paradigm characteristics and despite heterogeneity in adversity operationalization and assessment.
2. 1. Medicine

   Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states

   Gordon L Klein

   Phosphate and calcium from resorbing bone can find their way to the coronary circulation and contribute to atherosclerotic calcification of the blood vessels.
3. 1. Computational and Systems Biology

   Statistical and computational methods for integrating microbiome, host genomics, and metabolomics data

   Rebecca A Deek, Siyuan Ma ... Hongzhe Li

   Advanced statistical and computational methods are reviewed and compared for integrating microbiome, host genomics, and metabolomics data, together with future research directions.
4. 1. Epidemiology and Global Health

   Misstatements, misperceptions, and mistakes in controlling for covariates in observational research

   Xiaoxin Yu, Roger S Zoh ... David B Allison

   This quick reference guide for researchers addresses common misconceptions in the use of covariates in observational research and offers tips for preventing misstatements and mistakes.
5. 1. Cancer Biology

   Recording and classifying MET receptor mutations in cancers

   Célia Guérin, David Tulasne

   Classification of MET mutations allows a better understanding of sensitivity and resistance to targeted therapies used in cancer.
6. 1. Medicine

   Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast–osteoblast communication and potential clinical implications

   Valentina Daponte, Katrin Henke, Hicham Drissi

   A comprehensive review focusing on the role of osteoclasts as active regulators of bone homeostasis by influencing osteoblast function explores the currently known mechanisms and coupling factors involved in osteoclast–osteoblast communication and their potential as treatments for bone diseases.
7. 1. Immunology and Inflammation

   Variation in the basal immune state and implications for disease

   Aisha Souquette, Paul G Thomas

   An integrative conceptual and mathematical framework of immune variation that includes unique basal profiles associated with differential susceptibility to disease, distinct acute immune signatures associated with disease severity, and how different determinants can lead to individual pathways of illness outcome.
8. 1. Neuroscience

   Designing optimal behavioral experiments using machine learning

   Simon Valentin, Steven Kleinegesse ... Christopher G Lucas

   Recent advances in Bayesian optimal experimental design have made it possible to improve the efficiency and informativeness of experiments using machine learning, and shed new light on considerations that affect machine learning assisted experimental designs and computational models in general.
9. 1. Cell Biology

   Location, location, location: Protein kinase nanoclustering for optimised signalling output

   Rachel S Gormal, Ramon Martinez-Marmol ... Frédéric A Meunier

   This article reviews the latest studies that have used super-resolution microscopy and cluster analysis methodologies to study the mechanism of protein kinase signalling hubs and their organisation at nanoscale.
10. 1. Ecology
    2. Evolutionary Biology

    Sensory collectives in natural systems

    Hannah J Williams, Vivek H Sridhar ... Amanda D Melin

    A synthetic, prospective article considers how the fields of sensory ecology and collective behaviour can combine when considering animal collective movements and interactions, and how these fields can inspire each other to advance understanding of animal behaviour, adaptation and evolution.