Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Biochemistry and Chemical Biology

    Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses

    Jue Shi et al.
    Organ-selective drug action of traditional Chinese medicine that generates systemic immune mediators is proposed and reviewed as a novel mechanistic angle to develop new immunomodulatory drugs.
    1. Cell Biology

    The right time for senescence

    Diogo Paramos-de-Carvalho et al.
    A time-gated model is proposed to reconcile the transient vs. persistent biological activities of cellular senescence, in which 'time' seems to be the main orchestrator of the beneficial vs. detrimental effects of the senescent programme.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

    Nicole Laurencia Yuwono et al.
    Circulating cell-free DNA studies should control for participants' physical activity to avoid its confounding effect on total cell-free DNA level.
    1. Neuroscience

    Skipping ahead: A circuit for representing the past, present, and future

    Jennifer C Robinson, Mark P Brandon
    A circuit between the hippocampus, nucleus reunions, and prefrontal cortex organizes information about the past, present, and future into alternating theta sequences.
    1. Developmental Biology

    Y chromosome functions in mammalian spermatogenesis

    Jeremie Subrini, James Turner
    The mammalian Y chromosome has become specialised for male fertility, but exact functions of individual Y genes remain poorly understood, a knowledge gap that new approaches can bridge.
    1. Cell Biology
    2. Physics of Living Systems

    Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics

    Mohammad Mofatteh et al.
    Latest advances in biological timing studies substantiate an emerging concept of autonomous clocks that are normally entrained by the cell cycle and/or the circadian clock to run in synchrony, but have evolved to run independently to regulate different cellular events.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

    Srijan Seal et al.
    An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
    1. Developmental Biology
    2. Evolutionary Biology

    Studying evolution of the primary body axis in vivo and in vitro

    Kerim Anlas, Vikas Trivedi
    The shared capacity of stem cells to recapitulate initial body plan formation in vitro without species-specific cues, suggests the existence of alternative, evolutionarily conserved developmental trajectories.
    1. Neuroscience

    Understanding neural signals of post-decisional performance monitoring: An integrative review

    Kobe Desender et al.
    A computationally explicit framework can explain post-decisional neural signals of performance monitoring.
    1. Ecology

    How will mosquitoes adapt to climate warming?

    Lisa I Couper et al.
    Mosquitoes may be likely to adapt to climate warming given their short life cycles and strong temperature sensitivity, but key data gaps identified here constrain current estimates of adaptive potential.