It is proposed that innate immune cells are positioned to activate the naïve B cell repertoire and rational application of training stimuli could enforce this, offsetting original antigenic sin, wherein recall of ‘off-target’ B cell memory can obscure vaccine effectiveness.
Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.
Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn
Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.
Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford
Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
Luis Abdala-Roberts, Adriana Puentes ... Kailen A Mooney
Ecological network management provides key mechanistic knowledge on ecosystem degradation that links species- to ecosystem-level responses to global change, and emerging technological tools offer the opportunity to accelerate its widespread adoption.
The term 'parasympathetic', unlike the term 'sympathetic', unduly unifies an assemblage of autonomic pathways which are unrelated by anatomy, physiology or genetics, and whose distinction can foster a better understanding of the autonomic nervous system.
