Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Genetics and Genomics

    Beyond the RNA-dependent function of LncRNA genes

    Tamer Ali, Phillip Grote
    Recent examples demonstrate that already the transcriptional activity at lncRNA genes does have an important function on gene regulation, while the produced non-coding RNA might be dispensable.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: what have we learned in 50 years?

    J Dylan Shropshire et al.
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
    1. Medicine

    Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions

    Ilja L Kruglikov et al.
    Dysfunctionaladipose tissue puts obese and type 2 diabetic patients at higher risk.
    1. Developmental Biology
    2. Genetics and Genomics

    Speciation and the developmental alarm clock

    Asher D Cutter, Joanna D Bundus
    Integrating speciation genetics with ontogeny can identify predictable rules in the molecular evolution of developmental pathways and in the accumulation of reproductive isolation as genomes diverge.
    1. Cancer Biology
    2. Immunology and Inflammation

    A perspective on HPK1 as a novel immuno-oncology drug target

    Sansana Sawasdikosol, Steven Burakoff
    HPK1 is an important immuno-oncology drug target that may induce superior anti-tumor immunity through the multiple roles HPK1 may play at multiple steps of the cancer immunity cycle.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans

    L Ryan Baugh, Troy Day
    Evidence is mounting that environmentally-induced adaptive changes in phenotype can be transmitted across generations, but mechanistic gaps and theoretical concerns must be addressed to impact mainstream views of evolutionary adaptation.
    1. Medicine

    Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

    Tiziana Squillaro et al.
    An update on the role of lncRNAs in adipogenesis and adipose tissue function, aimed at promoting the identification of new drug targets for obesity and metabolic diseases.
    1. Medicine

    Neuropathogenesis of SARS-CoV-2 infection

    Shumayila Khan, James Gomes
    Clinical data of SARS-CoV-2 patients presenting atypical symptoms must be recorded systematically to support continuing research investigating neurological complications associated with COVID-19.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    New insights into the mechanism of dynein motor regulation by lissencephaly-1

    Steven M Markus et al.
    The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.