Review Articles

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases

   Aaron W Jurrjens, Marcus M Seldin ... Anna C Calkin

   The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated.
2. 1. Neuroscience

   Extra-hippocampal contributions to pattern separation

   Tarek Amer, Lila Davachi

   The ability to discriminate highly overlapping events in memory is a multistage process supported by a network of brain regions and neocortical–hippocampal interactions.
3. 1. Medicine
   2. Neuroscience

   The role of expectations, control and reward in the development of pain persistence based on a unified model

   Christian Büchel

   The integration of established psychological and biological models of pain suggests novel interventions to prevent pain persistence.
4. 1. Neuroscience

   Open-source tools for behavioral video analysis: Setup, methods, and best practices

   Kevin Luxem, Jennifer J Sun ... Mark Laubach

   Methods for video analysis of behaving animals are described, with guidance provided on setting up the methods in a research laboratory and best practices for experimenters and developers.
5. 1. Cancer Biology
   2. Medicine

   A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation

   Jeffrey West, Fred Adler ... Alexander RA Anderson

   Open questions of cancer adaptive therapy are discussed through the lens of mathematical modeling, categorized into three sections, (1) integrating appropriate components into mathematical models, (2) dosing protocol design and validation, and (3) challenges and opportunities in clinical translation.
6. 1. Epidemiology and Global Health
   2. Immunology and Inflammation

   Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

   Zaki A Sherif, Christian R Gomez ... RECOVER Mechanistic Pathway Task Force

   PASC (post-acute sequelae of SARS-CoV-2 infection) is an enduring and debilitating illness caused by a persistent virus that promotes inflammation, coagulation, and autoimmunity complications in millions of patients initially diagnosed with COVID-19, but with no known standardized treatment regimen.
7. 1. Genetics and Genomics

   Native functions of short tandem repeats

   Shannon E Wright, Peter K Todd

   The mechanisms by which non-pathologic short tandem repeats normally influence gene expression and engender rapid genetic variation across phylogeny directly inform how expansions in these same repeats elicit neurological disease.
8. 1. Neuroscience

   The integrated brain network that controls respiration

   Friedrich Krohn, Manuele Novello ... Laurens WJ Bosman

   The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.
9. 1. Cancer Biology

   The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

   Katarína Balážová, Hans Clevers, Antonella FM Dost

   As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.
10. 1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

    Emily Martyn, Sarah Eisen ... Philippa C Matthews

    Hepatitis B virus infection is a neglected challenge among communities who are under-served by conventional models of healthcare, requiring enhanced interventions to reduce inequity.