Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Immunology and Inflammation

    Coevolutionary interplay: Helminths-trained immunity and its impact on the rise of inflammatory diseases

    Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
    Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
    1. Ecology

    Connecting the dots: Managing species interaction networks to mitigate the impacts of global change

    Luis Abdala-Roberts, Adriana Puentes ... Kailen A Mooney
    Ecological network management provides key mechanistic knowledge on ecosystem degradation that links species- to ecosystem-level responses to global change, and emerging technological tools offer the opportunity to accelerate its widespread adoption.
    1. Neuroscience

    Gaskell, Langley, and the "para-sympathetic" idea

    Jean-François Brunet
    The term 'parasympathetic', unlike the term 'sympathetic', unduly unifies an assemblage of autonomic pathways which are unrelated by anatomy, physiology or genetics, and whose distinction can foster a better understanding of the autonomic nervous system.
    1. Structural Biology and Molecular Biophysics

    The known unknowns of the Hsp90 chaperone

    Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych
    An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
    1. Neuroscience

    Restoring vestibular function during natural self-motion: Progress and challenges

    Kantapon Pum Wiboonsaksakul, Olivia ME Leavitt Brown, Kathleen E Cullen
    Fully incorporating our current understanding of vestibular neurophysiology into prosthesis design and clinical application will be integral to the development of the next generation of vestibular prostheses.
    1. Genetics and Genomics

    Understanding genetic variants in context

    Nasa Sinnott-Armstrong, Stanley Fields ... Christine Queitsch
    Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.
    1. Neuroscience

    The BRAIN Initiative data-sharing ecosystem: Characteristics, challenges, benefits, and opportunities

    Sudhanvan Iyer, Kathryn Maxson Jones ... Mary A Majumder
    The BRAIN Initiative data-sharing ecosystem, consisting of seven data archives, faces interoperability and data stewardship challenges but nevertheless offers adaptability to the needs of particular research communities and raw material for network evolution.
    1. Neuroscience

    The gamma rhythm as a guardian of brain health

    Ana Maria Ichim, Harald Barzan ... Raul Cristian Muresan
    Fast oscillations (30-150Hz), generated by internal brain mechanisms may be essential for the maintenance of healthy brain function.
    1. Medicine
    2. Neuroscience

    Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research

    Alberto Granzotto, Bryce Vissel, Stefano L Sensi
    A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
    1. Structural Biology and Molecular Biophysics

    Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

    Julia Belyaeva, Matthias Elgeti
    Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.