Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Medicine

    A global view of the aspiring physician-scientist

    Christopher S Williams, W Kimryn Rathmell ... Mone Zaidi
    Challenges faced by the declining global workforce of young physician-scientists are highlighted, and a unified view on how to revive and reinvigorate this critical pool of dual-trained physicians worldwide is provided.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity

    Siavash Mansouri, Daniel Heylmann ... Rajkumar Savai
    The crosstalk between cancer cell genomic features and the tumor microenvironment (TME) to reveal the impact of genetic alterations on the TME phenotype.
    1. Cell Biology
    2. Ecology

    Ecological lipidology

    Laura Christin Trautenberg, Marko Brankatschk ... Klaus Reinhardt
    Effects of dietary lipids on organismal function and reproductive fitness are persistent and may depend on lipid identity, cause the evolution of lipid-based diet choice, alter food webs, change species responses to environmental change, and affect human nutrition.
    1. Neuroscience

    Amygdala-cortical collaboration in reward learning and decision making

    Kate M Wassum
    A review of a neuronal circuit architecture that helps us to learn about rewarding events and then to use that information to support adaptive decision making.
    1. Cancer Biology

    Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata

    Michael Ohh, Cassandra C Taber ... Daniel Tarade
    Previous studies and emerging data on pseudohypoxic diseases suggest that the complex phenotypic spectrum of VHL disease is due to the extent of HIF pathway deregulation in susceptible cell types and not by other purported substrates or functions of pVHL.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination

    Andrea J Lund, Kristen J Wade ... Elizabeth J Carlton
    Genomic approaches can be integrated with epidemiological and ecological studies to provide high-resolution answers to open questions about schistosomiasis transmission dynamics, offering a level of precision that is actionable, such that schistosomiasis-control programming can be tailored to regional contexts.
    1. Computational and Systems Biology
    2. Ecology

    Data-driven causal analysis of observational biological time series

    Alex Eric Yuan, Wenying Shou
    Visualizations, simulations, and examples are used to provide an accessible synthesis of the reasoning and assumptions behind commonly used causal discovery approaches.
    1. Neuroscience

    Understanding implicit sensorimotor adaptation as a process of proprioceptive re-alignment

    Jonathan S Tsay, Hyosub Kim ... Richard B Ivry
    A new computational model reveals how implicit sensorimotor adaptation is elicited to re-align one's felt and desired hand position.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Hematopoietic plasticity mapped in Drosophila and other insects

    Dan Hultmark, István Andó
    A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
    1. Medicine

    Evolution of multiple omics approaches to define pathophysiology of pediatric acute respiratory distress syndrome

    Jane E Whitney, In-Hee Lee ... Sek Won Kong
    Multiple -omics approaches have provided valuable insight into the pathobiology of pediatric acute respiratory distress syndrome, and novel unbiased techniques hold promise for future discoveries.