The term 'parasympathetic', unlike the term 'sympathetic', unduly unifies an assemblage of autonomic pathways which are unrelated by anatomy, physiology or genetics, and whose distinction can foster a better understanding of the autonomic nervous system.
Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych
An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
Kantapon Pum Wiboonsaksakul, Olivia ME Leavitt Brown, Kathleen E Cullen
Fully incorporating our current understanding of vestibular neurophysiology into prosthesis design and clinical application will be integral to the development of the next generation of vestibular prostheses.
Nasa Sinnott-Armstrong, Stanley Fields ... Christine Queitsch
Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.
Sudhanvan Iyer, Kathryn Maxson Jones ... Mary A Majumder
The BRAIN Initiative data-sharing ecosystem, consisting of seven data archives, faces interoperability and data stewardship challenges but nevertheless offers adaptability to the needs of particular research communities and raw material for network evolution.
A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
A broad and inclusive view of sex biases in hybrid dysfunction, irrespective of sexual system, expands the reach of Haldane's rule to help characterize the underlying forces and mechanisms responsible for predictable sex biases in evolutionary divergence and speciation.
The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
