Early oocyte development takes place in germline cysts and is strikingly conserved from Drosophila to mouse, reflecting common mechanisms that may help reverse aging and specify oocyte and early embryo polarity.
All the characteristic traits of the eukaryotic cell, the basic unit of all macroscopic life, commenced to originate in a prokaryote as means to serve an endosymbiont today known as mitochondria.
Christopher S Williams, W Kimryn Rathmell ... Mone Zaidi
Challenges faced by the declining global workforce of young physician-scientists are highlighted, and a unified view on how to revive and reinvigorate this critical pool of dual-trained physicians worldwide is provided.
Siavash Mansouri, Daniel Heylmann ... Rajkumar Savai
The crosstalk between cancer cell genomic features and the tumor microenvironment (TME) to reveal the impact of genetic alterations on the TME phenotype.
Laura Christin Trautenberg, Marko Brankatschk ... Klaus Reinhardt
Effects of dietary lipids on organismal function and reproductive fitness are persistent and may depend on lipid identity, cause the evolution of lipid-based diet choice, alter food webs, change species responses to environmental change, and affect human nutrition.
A review of a neuronal circuit architecture that helps us to learn about rewarding events and then to use that information to support adaptive decision making.
Previous studies and emerging data on pseudohypoxic diseases suggest that the complex phenotypic spectrum of VHL disease is due to the extent of HIF pathway deregulation in susceptible cell types and not by other purported substrates or functions of pVHL.
Andrea J Lund, Kristen J Wade ... Elizabeth J Carlton
Genomic approaches can be integrated with epidemiological and ecological studies to provide high-resolution answers to open questions about schistosomiasis transmission dynamics, offering a level of precision that is actionable, such that schistosomiasis-control programming can be tailored to regional contexts.
