Hypotheses on brain homologies between insects and vertebrates are tested by comparing gene expression patterns from flies and beetles with those from vertebrates at early neuroectoderm stages.
C Kim, Benjamin Chen ... RECOVER Mechanistic Pathways Task Force
Collaborative and mutually beneficial patient-provider-researcher relationships are crucial in achieving success in understanding and treating long COVID.
The expansion of our understanding about the regulation of iron metabolism, erythropoiesis, and the crosstalk between them has enabled delineating the pathophysiology of multiple diseases and provided rationale for novel therapeutic interventions.
Measurement precision offers a comprehensive perspective on good scientific practices to improve reproducibility of research results by providing means to optimize design and analysis parameters (e.g. sample size, trial count, or sample heterogeneity) in accordance with the researcher’s goals.
Daniel A Armendariz, Anjana Sundarrajan, Gary C Hon
Continuing advances in functional genomics will enable systematic characterization of how non-coding genetic variation at enhancers impacts developmental diseases.
A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.
Understanding protein kinase regulation by activation loop autophosphorylation depends on a critical assessment of experimental design, execution, and interpretation.
Theoretical analysis of the current literature reveals the structural assembly, transport regulation, and molecular functions of the BBSome, emphasizing its roles in cilium-related processes.
Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala
Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.
