Review Articles

Review Articles are intended to bring readers up-to-date with research on important topics. Review Articles are commissioned by Senior Editors.

Latest articles

    1. Computational and Systems Biology
    2. Genetics and Genomics

    The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases

    Aaron W Jurrjens, Marcus M Seldin ... Anna C Calkin
    The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated.
    1. Neuroscience

    Extra-hippocampal contributions to pattern separation

    Tarek Amer, Lila Davachi
    The ability to discriminate highly overlapping events in memory is a multistage process supported by a network of brain regions and neocortical–hippocampal interactions.
    1. Medicine
    2. Neuroscience

    The role of expectations, control and reward in the development of pain persistence based on a unified model

    Christian Büchel
    The integration of established psychological and biological models of pain suggests novel interventions to prevent pain persistence.
    1. Neuroscience

    Open-source tools for behavioral video analysis: Setup, methods, and best practices

    Kevin Luxem, Jennifer J Sun ... Mark Laubach
    Methods for video analysis of behaving animals are described, with guidance provided on setting up the methods in a research laboratory and best practices for experimenters and developers.
    1. Cancer Biology
    2. Medicine

    A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation

    Jeffrey West, Fred Adler ... Alexander RA Anderson
    Open questions of cancer adaptive therapy are discussed through the lens of mathematical modeling, categorized into three sections, (1) integrating appropriate components into mathematical models, (2) dosing protocol design and validation, and (3) challenges and opportunities in clinical translation.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

    Zaki A Sherif, Christian R Gomez ... RECOVER Mechanistic Pathway Task Force
    PASC (post-acute sequelae of SARS-CoV-2 infection) is an enduring and debilitating illness caused by a persistent virus that promotes inflammation, coagulation, and autoimmunity complications in millions of patients initially diagnosed with COVID-19, but with no known standardized treatment regimen.
    1. Genetics and Genomics

    Native functions of short tandem repeats

    Shannon E Wright, Peter K Todd
    The mechanisms by which non-pathologic short tandem repeats normally influence gene expression and engender rapid genetic variation across phylogeny directly inform how expansions in these same repeats elicit neurological disease.
    1. Neuroscience

    The integrated brain network that controls respiration

    Friedrich Krohn, Manuele Novello ... Laurens WJ Bosman
    The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.
    1. Cancer Biology

    The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

    Katarína Balážová, Hans Clevers, Antonella FM Dost
    As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

    Emily Martyn, Sarah Eisen ... Philippa C Matthews
    Hepatitis B virus infection is a neglected challenge among communities who are under-served by conventional models of healthcare, requiring enhanced interventions to reduce inequity.