Review Articles

Latest articles

1. 1. Neuroscience

   Traveling waves across scales: Different mechanisms but same canonical computation?

   Laura Dugué, Frédéric Chavane

   The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computational syntax.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective

   Timothy J Henrich, Christopher P Montgomery ... Maria Laura Gennaro

   Unraveling mechanisms underlying post-acute SARS-CoV-2 sequelae (long COVID) and finding therapeutic solutions require a full understanding of the causative role of SARS-CoV-2 persistence and/or infection with other microorganisms, which may be pre-existing, concurrent, or subsequent to acute COVID-19.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Innate immune memory: The evolving role of macrophages in therapy

   Payal Damani-Yokota, Kamal Mohan Khanna

   Epigenetic and metabolic programming of innate immune cells shapes host defense and disease susceptibility.
4. 1. Computational and Systems Biology
   2. Medicine

   Critique of impure reason: Unveiling the reasoning behaviour of medical large language models

   Shamus Zi Yang Sim, Tyrone Chen

   A survey of reasoning behaviour in medical large language models uncovers emerging trends, highlights open challenges, and introduces theoretical frameworks that enhance reasoning behaviour transparency, ultimately fostering greater trust among clinicians, developers, and patients in their deployment.
5. 1. Genetics and Genomics

   Rewiring the bone marrow: Evolution and the transcriptional architecture of trained immunity

   Sarah J Sun, Raúl Aguirre-Gamboa, Luis B Barreiro

   Hematopoietic reprogramming reflects the selective and evolutionarily conserved engagement of transcription factor networks that encode innate immune memory in long-lived stem cells.
6. 1. Immunology and Inflammation

   Resident memory macrophages and trained innate immunity at barrier tissues

   Alisha Kang, Michael D'Agostino ... Zhou Xing

   The increasing knowledge of barrier tissue-resident memory macrophages and trained innate immunity (TII) will help develop both nontarget-specific and target-specific TII-based vaccine strategies.
7. 1. Immunology and Inflammation

   Metabolic regulation of immune memory and function of microglia

   Nikolaos Nirakis, Sofia Dimothyra ... Vasileia Ismini Alexaki

   Cell metabolic processes, particularly glucose, glutamine, and lipid metabolism, orchestrate inflammatory responses and promote epigenetic changes shaping microglia immune memory.
8. 1. Immunology and Inflammation

   Trained immunity in skin infections: Macrophages and beyond

   Vitka Gres, Merve Göcer ... Philipp Henneke

   Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.
9. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Understanding the global rise of artemisinin resistance: Insights from over 100,000 Plasmodium falciparum samples

   Andrew J Balmer, Nina FD White ... Cristina Ariani

   Spatiotemporal analysis of global kelch13 surveillance data reveals that artemisinin resistance is increasing in East Africa, mirroring patterns previously observed in Southeast Asia.
10. 1. Immunology and Inflammation

    Hematopoietic stem and progenitor cells as a reservoir for trained immunity

    Brandon T Tran, Vidthiya Jeyanathan ... Katherine Y King

    Inflammation supports selection, differentiation bias, and epigenetic reprogramming of hematopoietic stem and progenitor cells to generate innate immune memory.