Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn
Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.
Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.
Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford
Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
Luis Abdala-Roberts, Adriana Puentes ... Kailen A Mooney
Ecological network management provides key mechanistic knowledge on ecosystem degradation that links species- to ecosystem-level responses to global change, and emerging technological tools offer the opportunity to accelerate its widespread adoption.
The term 'parasympathetic', unlike the term 'sympathetic', unduly unifies an assemblage of autonomic pathways which are unrelated by anatomy, physiology or genetics, and whose distinction can foster a better understanding of the autonomic nervous system.
Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych
An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
