Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

  1. Naotaka Tsutsumi
  2. Somnath Mukherjee
  3. Deepa Waghray
  4. Claudia Y Janda
  5. Kevin M Jude
  6. Yi Miao
  7. John S Burg
  8. Nanda Gowtham Aduri
  9. Anthony A Kossiakoff
  10. Cornelius Gati  Is a corresponding author
  11. K Christopher Garcia  Is a corresponding author
  1. Stanford University School of Medicine, United States
  2. The University of Chicago, United States
  3. Princess Máxima Center for Pediatric Oncology, Netherlands
  4. SLAC National Accelerator Laboratory, United States
  5. Howard Hughes Medical Institute, Stanford University School of Medicine, United States
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  1. Naotaka Tsutsumi
  2. Somnath Mukherjee
  3. Deepa Waghray
  4. Claudia Y Janda
  5. Kevin M Jude
  6. Yi Miao
  7. John S Burg
  8. Nanda Gowtham Aduri
  9. Anthony A Kossiakoff
  10. Cornelius Gati
  11. K Christopher Garcia
(2020)
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
eLife 9:e58464.
https://doi.org/10.7554/eLife.58464