Genome expansion in early eukaryotes drove the transition from lateral gene transfer to meiotic sex
- CoMPLEX, University College London, United Kingdom
- Department of Genetics, Evolution and Environment University College London, United Kingdom
Figures
Figure 1
Model dynamics.
After the birth of a new generation, eDNA is acquired from the environment and randomly recombined with recombination length , at a rate per genome. Following LGT, mutations are randomly …
Figure 2
Impact of LGT and genome size on the ratchet.
The mean extinction time (generations) of the Least-Loaded Class () is shown as a function of genome size () for various recombination lengths (), in the presence of (A) low () and (B) high …
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Figure 2—source data 1
Time of extinction of least loaded class.
- https://cdn.elifesciences.org/articles/58873/elife-58873-fig2-data1-v1.mat.zip
Figure 3
Impact of LGT and genome size on the rate of accumulation of mutation.
The mean genome-wide rate of fixation of deleterious mutations per generation, calculated over a time interval generations, as a function of genome size () for various recombination lengths ()…
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Figure 3—source data 1
Rate of accumulation of mutations with variable genome-wide mutation rate.
- https://cdn.elifesciences.org/articles/58873/elife-58873-fig3-data1-v1.mat.zip
Figure 4
Rate of fixation of mutations with constant genome-wide mutation rate.
The mean genome-wide rate of fixation of deleterious mutations per generation. This is shown for a low rate genome-wide mutation rate for (A) low () and (B) high () LGT rates, and a high …
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Figure 4—source data 1
Rate of fixation of mutations with constant genome-wide mutation rate.
- https://cdn.elifesciences.org/articles/58873/elife-58873-fig4-data1-v1.mat.zip
Figure 5
| Fixation of mutations in the core and accessory genome.
Fixed mutations in the core and accessory genome after generations for no LGT with (A) small () and (B) large () genome size, and for LGT (, ) with (C) small () and (D) large () …
Figure 6
Rate of fixation of mutations in the core and accessory genome.
The fixation of mutants in (A) the core and (B) the accessory genome is shown after generations, normalised by genome size. A higher number of mutations accumulate in the accessory genome that is …
Appendix 1—figure 1
Genome size and population size determine .
The equilibrium number of individuals in the least-loaded class () is shown as a function of genome size (number of loci) and population size, with constant mutation rate and constant strength …
Tables
Table 1
Parameters and variables.
| population size | |
| mutation rate per locus per generation | |
| genome size (number of loci) | |
| genome-wide mutation rate | |
| strength of selection against deleterious mutations | |
| LGT rate | |
| recombination length (number of loci) |
