(A) Example grid (i), head direction (ii), and speed (iii) cells taken from the highest modulation scores from WT (top) and rTg4510 (bottom) mice, showing spatial firing patterns with 2D spatial autocorrelation, head-direction tuning and running speed-firing rate relationship and corresponding score (SI: spatial information, HD: mean vector length, Z: speed score). (B) Proportions of grid, head-direction, and speed-modulated cells recorded in mEC, showing reduced number of grid and speed, but not head-direction, cells passing threshold (95% centile of shuffled distribution). (C) Conjunctive proportions of grid cells (i), head-direction cells (ii), and speed-modulated cells (iii) recorded from WT and rTg4510 mice scaled to 100%. (D) Breakdown of units from WT and rTg4510 mice that satisfied a single criteria (class), multiple criteria (conj) or no discernible firing pattern (other). Key, G: grid, S: speed, HD: head direction, G-S: grid-speed, G-HD: grid-head direction, G-S-HD: grid-speed-head direction, SnegHD: negative speed–head-direction, Sneg: negative speed, Class: classed as cell type, Conj: conjunctive representation (more than 1 classification), other: not classified as grid, speed or HD.