Synaptic memory requires CaMKII
- Fujian Medical University, China
- University of California, San Francisco, United States
Abstract
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP ('learning') are well understood, the maintenance of LTP ('memory') has remained contentious over the last 20 years. Here, we find that CaMKII contributes to synaptic transmission and is required LTP maintenance. Acute inhibition of CaMKII erases LTP and transient inhibition of CaMKII enhances subsequent LTP. These findings strongly support the role of CaMKII as a molecular storage devise.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting files.
Article and author information
Author details
Javier Díaz-Alonso
Samuel Pleasure, M.D., Ph.D.
Funding
No external funding was received for this work.
Ethics
Animal experimentation: All the experimental procedures on animals were approved by the UCSF Animal Care and Use Committee, BUA # BU002466-04C
Copyright
© 2021, Tao et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 5,896
- views
-
- 1,011
- downloads
-
- 51
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Synaptic memory requires CaMKII
eLife 10:e60360.
https://doi.org/10.7554/eLife.60360
