Coupling between fast and slow oscillator circuits in Cancer borealis is temperature compensated

  1. Daniel Powell
  2. Sara A Haddad
  3. Srinivas Gorur-Shandilya
  4. Eve Marder  Is a corresponding author
  1. Bowdoin College, United States
  2. University of Zürich, Irchel, Switzerland
  3. Brandeis University, United States

Abstract

Coupled oscillatory circuits are ubiquitous in nervous systems. Given that most biological processes are temperature sensitive, it is remarkable that the neuronal circuits of poikilothermic animals can maintain coupling across a wide range of temperatures. Within the stomatogastric ganglion (STG) of the crab, Cancer borealis, the fast pyloric rhythm (~1Hz) and the slow gastric mill rhythm (~0.1Hz) are precisely coordinated at ~11°C such that there is an integer number of pyloric cycles per gastric mill cycle (integer coupling). Upon increasing temperature from 7-23°C, both oscillators showed similar temperature-dependent increases in cycle frequency, and integer coupling between the circuits was conserved. Thus, although both rhythms show temperature dependent changes in rhythm frequency, the processes that couple these circuits maintain their coordination over a wide range of temperature. Such robustness to temperature changes could be part of a toolbox of processes that enables neural circuits to maintain function despite global perturbations.

Data availability

All electrophysiological data and analysis code has been uploaded to a publicly available data base: Scripts to reproduce all figures in this paper are available at https://github.com/marderlab/gastric. Raw data and spike annotations can be downloaded from https://zenodo.org/record/3924718.

Article and author information

Author details

  1. Daniel Powell

    Biology Department, Bowdoin College, Brunswick, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Sara A Haddad

    Department of Molecular Life Sciences, University of Zürich, Irchel, Zurich, Switzerland
    Competing interests
    The authors declare that no competing interests exist.
  3. Srinivas Gorur-Shandilya

    Volen Center, Brandeis University, Waltham, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. Eve Marder

    Volen Center, Brandeis University, Waltham, United States
    For correspondence
    marder@brandeis.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9632-5448

Funding

National Institute of Neurological Disorders and Stroke (R35 NS 097343)

  • Eve Marder

National Institute of Neurological Disorders and Stroke (T32 07292)

  • Srinivas Gorur-Shandilya

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Claire Wyart, Institut du Cerveau et la Moelle épinière, Hôpital Pitié-Salpêtrière, Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, France

Version history

  1. Received: June 26, 2020
  2. Accepted: February 1, 2021
  3. Accepted Manuscript published: February 4, 2021 (version 1)
  4. Version of Record published: February 17, 2021 (version 2)

Copyright

© 2021, Powell et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Daniel Powell
  2. Sara A Haddad
  3. Srinivas Gorur-Shandilya
  4. Eve Marder
(2021)
Coupling between fast and slow oscillator circuits in Cancer borealis is temperature compensated
eLife 10:e60454.
https://doi.org/10.7554/eLife.60454

Share this article

https://doi.org/10.7554/eLife.60454

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