(A) Reduction of full model (right) to a single branch (middle) reproduces sequence discrimination (right), full model in gray, and reduced model colored for different time-steps between inputs, centripetal (dashed), and centrifugal (dash-dotted). (B) Full model (left) and three-compartment reduction (middle, bottom) discriminate temporal order of inputs, where the response to inputs (middle, top) ordered is stronger than . Voltage responses (right) in full model (gray) and reduced model (colored). (C, D) Reductions of resp. L5 pyramidal and Purkinje cells with active ion channels at the soma, and excitatory (AMPA+NMDA) and inhibitory (GABA) synapses at dendritic compartment sites. From left to right: full model with compartment sites (soma S and a selected dendrite site D are labeled), reduced model, somatic voltage with zoom on a single AP (full model in gray and reduced model in purple, input spikes at the bottom), dendritic voltage at D (full model in gray and reduced model in green, input spikes at the bottom), and the relative root mean square voltage errors at each compartment (root mean squared error normalized by the standard deviation ). Spike coincidence factor is also shown.