Spontaneous and evoked activity patterns diverge over development
- The University of Queensland, Australia
Abstract
The immature brain is highly spontaneously active. Over development this activity must be integrated with emerging patterns of stimulus-evoked activity, but little is known about how this occurs. Here we investigated this question by recording spontaneous and evoked neural activity in the larval zebrafish tectum from 4 to 15 days post fertilisation. Correlations within spontaneous and evoked activity epochs were comparable over development, and their neural assemblies properties refined in similar ways. However both the similarity between evoked and spontaneous assemblies, and also the geometric distance between spontaneous and evoked patterns, decreased over development. At all stages of development evoked activity was of higher dimension than spontaneous activity. Thus spontaneous and evoked activity do not converge over development in this system, and these results do not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.
Data availability
The data has been made available on FigShare, under the DOI:10.6084/m9.figshare.14402543
-
Spontaneous and evoked activity patterns in the larval zebrafishFigShare, doi:10.6084/m9.figshare.14402543.
Article and author information
Author details
Geoffrey J Goodhill
Funding
Australian Research Council (DP170102263)
- Geoffrey J Goodhill
Australian Research Council (DP180100636)
- Geoffrey J Goodhill
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All procedures were performed with approval from The University of Queensland Animal Ethics Committee (QBI/152/16/ARC).
Copyright
© 2021, Avitan et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 3,143
- views
-
- 451
- downloads
-
- 27
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Spontaneous and evoked activity patterns diverge over development
eLife 10:e61942.
https://doi.org/10.7554/eLife.61942
