Spontaneous and evoked activity patterns diverge over development
Abstract
The immature brain is highly spontaneously active. Over development this activity must be integrated with emerging patterns of stimulus-evoked activity, but little is known about how this occurs. Here we investigated this question by recording spontaneous and evoked neural activity in the larval zebrafish tectum from 4 to 15 days post fertilisation. Correlations within spontaneous and evoked activity epochs were comparable over development, and their neural assemblies properties refined in similar ways. However both the similarity between evoked and spontaneous assemblies, and also the geometric distance between spontaneous and evoked patterns, decreased over development. At all stages of development evoked activity was of higher dimension than spontaneous activity. Thus spontaneous and evoked activity do not converge over development in this system, and these results do not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.
Data availability
The data has been made available on FigShare, under the DOI:10.6084/m9.figshare.14402543
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Spontaneous and evoked activity patterns in the larval zebrafishFigShare, doi:10.6084/m9.figshare.14402543.
Article and author information
Author details
Funding
Australian Research Council (DP170102263)
- Geoffrey J Goodhill
Australian Research Council (DP180100636)
- Geoffrey J Goodhill
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All procedures were performed with approval from The University of Queensland Animal Ethics Committee (QBI/152/16/ARC).
Reviewing Editor
- Tatyana O Sharpee, Salk Institute for Biological Studies, United States
Publication history
- Received: August 10, 2020
- Accepted: April 7, 2021
- Accepted Manuscript published: April 19, 2021 (version 1)
- Version of Record published: April 26, 2021 (version 2)
Copyright
© 2021, Avitan et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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