Science Forum: Improving preclinical studies through replications
- Department of Experimental Neurology, Charité–Universitätsmedizin, Germany
- BIH QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Germany
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Science Forum: Improving preclinical studies through replicationseLife 10:e62101.https://doi.org/10.7554/eLife.62101 - Cite
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Figures
Figure 1
Increasing different forms of validity (internal, external and translational) during a preclinical research trajectory.
This schematic shows that internal validity (green line) is higher than external validity (orange) and translational validity (blue) at the start of a preclinical research trajectory (left), and …
Tables
Table 1
Overview of three large-scale replication projects in biomedical research: Reproducibility Project: Cancer Biology (RPCB); Brazilian Reproducibility Initiative (BRI); Confirmatory Preclinical Studies (CPS).
| RPCB | BRI | CPS | |
|---|---|---|---|
| Selection of samples to be replicated | Main findings from 50 high impact citations/publications in cancer research | Replication of 60–100 experiments from research articles of Brazilian studies in different clinical areas | Two-step review process of proposals results in twelve projects |
| Selection of experiment | Main finding from published studies | Experiments using five pre-defined methods | Own experiments |
| Replicate own results | No | No | Yes |
| Exact Protocols | Yes (consulting original authors) | No | Yes |
| Blind to initial results | No | Yes | No |
| Pre-registration | Pre-registered study and individual Replication Protocols | Yes | Yes |
| Multi-site replication | No | Yes | Yes |
