(a-e) Correlations between echocardiography acquired metrics with experimental findings in tachycardia-induced cardiomyopathy (TIC) subjects included (a) tricuspid anterior leaflet area v. annular dilation (Pearson), (b) tricuspid regurgitation (TR) grade v. the ratio of anterior leaflet area to annular dimension (Spearman), (c) circumferential (Circ, left) and radial (Rad, right) calf stiffness v. TR grade (Spearman), (d) collagen content (Coll.) v. TR grade (Spearman), and (e) leaflet thickness v. TR grade (Spearman). Correlation coefficients (r) and p-values are inscribed in each panel, along with a linear fit (black, dashed) for visualization, if significant correlation exists. All statistical analyses here were based on specific hypotheses, and p-values thus reflect one-sided tests. (f) A correlation matrix of all combinations of TR grade, right ventricular dilation (RVD), annular dilation (AD) v. area, thickness (Thick), collagen content, calf stiffness in the circumferential (CSC) and radial (CSR) directions. Values within plot are p-values, while color map indicates the correlation coefficient (right). Correlations were Spearman’s correlation tests, unless p-value contains an asterisk (*), denoting use of a Pearson’s correlation test. Here, our significance threshold of 0.003 (Bonferroni correction) did not result in any significant correlations.