(A) Structural and dynamic information about the four proteins in the ErbB family of proteins (EGFR, Her2, Her3, and Her4) and their ligands. Top: Mechanism of action for EFGR which, upon ligand binding, undergoes a conformational change (130° movement) into the active extended conformation; it can also form a dimer with another active EGFR protein. Bottom: PDB structures, ligands and dimer partner combinations for Her2, Her3 and Her4. (B) The creation of stylized protein meshes starts with structures sourced from the PBD (top); the backbone is extruded and the structure is then refined to produce the mesh (bottom). (C) A 3D model of a lipid bilayer in a cancer cell, highlighting an asymmetric distribution of 400 lipids (data adapted from Shahane et al., 2019). The bilayer components include cholesterol (CHOL), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1-palmatoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS), and palmitoylsphingomyelin (PSM). The proportion of each lipid species within the outer and inner leaflets is shown on the left; the percentage of each species in the bilayer is shown on the right. The two hexagonal shapes are side views of a model cancer plasma membrane with proteins EGFR and GLUT1.