Mixed synapses reconcile violations of the size principle in zebrafish spinal cord
- Department of Neurobiology, Northwestern University, United States
Figures
Figure 1
Size-independent scaling of time constants and excitation with interneuron input resistance.
(a) Cross-section of spinal cord denoting canonical classes of molecularly defined locomotor-related interneurons. (b) Wiring diagram of swimming circuitry comprised of excitatory interneurons …
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Figure 1—source data 1
Source data from panels d, e and g in Figure 1.
- https://cdn.elifesciences.org/articles/64063/elife-64063-fig1-data1-v1.xlsx
Figure 2
Electrical and chemical postsynaptic potentials are differentially scaled to input resistance.
(a) Example of a mixed synaptic connection from a V2a-B neuron on slower (left) and faster (right) time scales. A brief current pulse (pre, gray traces at top left) evoked a mixed synaptic response …
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Figure 2—source data 1
Source data for panels d-l in Figure 2.
- https://cdn.elifesciences.org/articles/64063/elife-64063-fig2-data1-v1.xlsx
Figure 3
Simulations of convergent electrical and chemical synapses recapitulate experimental results.
(a) Schematic of the simulated network. A simulated interneuron forming chemical synapses (simChemIN, orange) with 10 simulated motor neuron (sim MNs, gray) somata ranging from 1 to 10 µm in …
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Figure 3—source data 1
Source data for panels d, e, f, and h in Figure 3.
- https://cdn.elifesciences.org/articles/64063/elife-64063-fig3-data1-v1.xlsx
