Robust vestibular self-motion signals in macaque posterior cingulate region
- CAS Center for Excellence in Brain Science and Intelligence Technology, Key Laboratory of Primate Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, China
- University of Chinese Academy of Sciences, China
Figures
Figure 1
Diagram of experimental set-up.
(A) Monkeys were translated or rotated by a 6-degree-of-freedom motion platform (MOOG). A visual display is mounted on the platform, providing visual stimuli that simulate real motion. (B) Motion …
Figure 2
Recording sites reconstructed on MRI images of three monkeys.
(A) Sagittal and coronal planes in one animal (monkey Q), with green shaded areas indicating PCC and red shaded areas indicating RSC. Electrode penetration is indicated by the dark shaded lines. (B–C…
Figure 3 with 2 supplements
PSTHs from two example neurons in the vestibular condition.
(A) Upper panels: PSTHs of an example PCC velocity-dominant neuron across 26 directions under the translation condition. The red dashed lines indicate the velocity peak time of velocity profile and …
Figure 3—figure supplement 1
PSTHs from the same two example neurons under rotation condition.
(A) Upper panels: PSTHs of the velocity-dominant neuron across 26 directions. The red dashed lines indicate the velocity peak time of velocity profile and the two blue dashed lines indicate the peak …
Figure 3—figure supplement 2
PSTHs from two example neurons in RSC.
(A) Upper panels: PSTHs of an example neuron across 26 directions under translation condition. The red dashed lines indicate the velocity peak time of velocity profile and the two blue dashed lines …
Figure 4 with 2 supplements
Population summary of temporal and spatial tuning properties of vestibular signals in PCC and RSC.
(A). Proportion of neurons in each category. (B) DDI distribution of neurons with significant temporal tuning. Filled bars indicate neurons with significant spatial tuning. (C) Distribution of …
Figure 4—figure supplement 1
Population summary of temporal and spatial tuning properties of vestibular signals according to the three monkeys.
(A). Proportion of neurons in each category. (B) DDI distribution of neurons with significant temporal tuning. Filled bars indicate neurons with significant spatial tuning. (C) Distribution of …
Figure 4—figure supplement 2
Population summary of temporal and spatial tuning properties of vestibular signals according to left and right hemispheres.
(A). Proportion of neurons in each category. (B) DDI distribution of neurons with significant temporal tuning. Filled bars indicate neurons with significant spatial tuning. (C) Distribution of …
Figure 5
Neural activity of an example neuron in total darkness and sound conditions.
(A–C) Responses from an example cell in the regular vestibular translation condition (A), total darkness condition (B), and sound control condition (C).
Figure 6
Population analysis in total darkness and sound conditions.
(A–C) Pearson correlation coefficient of PSTHs (A), DDI (B), maximum firing rate (C) between regular vestibular and total darkness conditions. Filled symbols indicate neurons with significant …
Figure 7 with 1 supplement
Fitting results of two example neurons with VA model.
(A–B) Upper panels: PSTHs of two example cells fitted by VA model. Gray areas are PSTHs and superimposed black lines are fitted data. Red dashed lines: peak time of velocity; Blue dashed lines: peak …
Figure 7—figure supplement 1
Illustration of the three-dimensional temporal-spatial model.
The full PVAJ model contains four different components, velocity, acceleration, jerk and position, which are summed linearly by their corresponding weights, with their own temporal kernel and …
Figure 8
Population results with VA model.
(A) Goodness of fit for PCC and RSC. Triangles are median value of each distribution. (B) Log ratio of the velocity weight to the acceleration weight. Triangles show the median value. Only data with …
Figure 9
Fitting results of two example neurons with PVAJ model.
(A–B) Upper panels: PSTHs of two example cells fitted by VA model. Gray areas are PSTHs and superimposed black lines are fitted data. Red dashed lines: peak time of velocity; Blue dashed lines: peak …
Figure 10
Population results with PVAJ model.
(A) Goodness of fit (R2) from the PVAJ model assessed by Pearson correlation between the experimental and fitted data. Triangles: median value. (B) Distribution of partial correlation coefficient …
Figure 11
Comparison between PCC and MSTd fitted with VA and PVAJ models.
(A) Distribution of goodness of fit (R2). Triangles: medians. (B) Left column: difference in the BIC (Bayesian Information Criterion) between the two models (BDI, BIC difference index, see Materials …
Figure 12 with 2 supplements
Visual self-motion signals (optic flow) in the posterior cingulate region.
(A) Proportion of temporal and spatial tuning in PCC and RSC. (B) Distributions of DDI. (C) Preferred direction. Symbol representations are same as in Figure 4.
Figure 12—figure supplement 1
Population summary of temporal and spatial tuning properties of visual signals according to the three monkeys.
(A) Proportion of neurons in each category. (B) DDI distribution of neurons with significant temporal tuning. Filled bars indicate neurons with significant spatial tuning. (C) Distribution of …
Figure 12—figure supplement 2
Population summary of temporal and spatial tuning properties of visual signals according to left and right hemispheres.
(A). Proportion of neurons in each category. (B) DDI distribution of neurons with significant temporal tuning. Filled bars indicate neurons with significant spatial tuning. (C) Distribution of …
Tables
Table 1
Temporal and spatial tuning properties across subregions of posterior cingulate area under different conditions.
| Subregion | Conditions | Vestibular | Visual | ||
|---|---|---|---|---|---|
| Temporally tuned | Spatially tuned | Temporally tuned | Spatially tuned | ||
| PCC | Translation | 252/372 (68%) | 189/252 (75%) | 114/367 (31%) | 41/114 (36%) |
| Rotation | 161/271 (59%) | 124/161 (77%) | 84/260 (32%) | 20/84 (24%) | |
| RSC | Translation | 37/114 (32%) | 5/37 (14%) | 13/114 (11%) | 0/13 (0%) |
| Rotation | 25/87 (29%) | 9/25 (36%) | 12/87 (14%) | 1/12 (1%) | |
Table 2
Temporal and spatial tuning properties under total darkness and sound control experiments.
Note in the sound control conditions, there is no neuron with significant temporal tuning, so we did not calculate the spatial tuning properties.
| Conditions | Dark control | Sound control | ||
|---|---|---|---|---|
| Temporally tuned | Spatially tuned | Temporally tuned | Spatially tuned | |
| Translation | 42/49 (86%) | 34/43 (79%) | 0/10 (0%) | / |
| Rotation | 16/18 (89%) | 15/16 (94%) | 0/1 (0%) | / |
