Partial residual plots for (a) normalised brain volume, (b) total grey volume, (c) total white volume, (d) left ventricular mass index, (e) left ventricular end-diastolic volume index, (f) left …
Brain grey matter | Brain white matter | Heart | Aorta | Liver | |
---|---|---|---|---|---|
N | 10,143 | 9053 | 11,821 | 12,376 | 3649 |
Baseline characteristics | |||||
Age (years) (mean ± SD) | 62.9 ± 7.4 | 62.9 ± 7.4 | 62.8 ± 7.4 | 63.0 ± 7.4 | 55.7 ± 7.5 |
Male (%) | 49.8 | 49.4 | 49.9 | 50.2 | 50.5 |
Caucasian (%) | 99.8 | 99.8 | 99.8 | 99.8 | 93.2 |
Educational attainment (%) | 53.2 | 53.5 | 53.5 | 52.9 | 53.1 |
Body mass index (mean ± SD) | 26.7 ± 4.4 | 26.6 ± 4.3 | 26.5 ± 4.3 | 26.5 ± 4.2 | 26.5 ± 4.1 |
Hypertension (%) | 39.6 | 39.3 | 39.0 | 39.1 | 46.5 |
Diabetes (%) | 5.2 | 5.0 | 4.7 | 4.9 | 2.5 |
Smoking history (%) | 39.7 | 39.4 | 38.6 | 39.1 | 36 |
Alcohol consumption (g/d) (median–IQR) | 14.29 (6.46–26.78) | 14.29 (6.26–26.79) | 14.29 (6.70–26.79) | 14.29 (6.69–26.79) | 16.61 (8.93–28.86) |
Imaging-derived phenotypes | Mean ± SD |
---|---|
Brain | |
Normalised brain volume | 0.72 ± 0.045 |
Normalised grey matter volume | 0.43 ± 0.034 |
Normalised white matter volume | 0.29 ± 0.020 |
Heart | |
Left ventricular mass index (g/m2) | 46.2 ± 8.5 |
Left ventricular end-diastolic volume index (ml/m2) | 80.0 ± 13.7 |
Left ventricular ejection fraction (%) | 59.6 ± 5.9 |
Left atrial volume index (ml/m2) | 38.8 ± 10.7 |
Right ventricular end-diastolic volume index (ml/m2) | 84.5 ± 15.4 |
Right ventricular ejection fraction (%) | 57.3 ± 6.0 |
Right atrial volume index (ml/m2) | 46.1 ± 13.1 |
Aorta | |
Ascending aortic area index (mm2/m2) | 455.3 ± 91.9 |
Ascending aortic distensibility (10−3mmHg−1) | 1.98 ± 1.17 |
Descending aortic area index (mm2/m2) | 254.1 ± 43.3 |
Descending aortic distensibility (10−3mmHg−1) | 2.64 ± 1.25 |
SD: standard deviation.
Aging/year, estimate* ± SE | p-value | Alcohol, estimate* ± SE | p-value | |
---|---|---|---|---|
Heart | ||||
Left ventricular mass index | −0.10 ± 0.01 | 1.3 × 10−31 | 0.36 ± 0.04 | 8.5 × 10−22 |
Left ventricular end-diastolic volume index | −0.33 ± 0.02 | 6.0 × 10−90 | 0.61 ± 0.07 | 4.1 × 10−17 |
Left ventricular ejection fraction (%) | 0.04 ± 0.01 | 6.3 × 10−7 | 0.05 ± 0.03 | 0.16 |
Left atrial volume index (ml/m2) | −0.12 ± 0.01 | 8.9 × 10−17 | 0.43 ± 0.06 | 6.0 × 10−12 |
Right ventricular end-diastolic volume index (ml/m2) | −0.33 ± 0.02 | 5.6 × 10−80 | 0.57 ± 0.08 | 2.5 × 10−13 |
Right ventricular ejection fraction (%) | 0.04 ± 0.01 | 1.6 × 10−8 | 0.05 ± 0.03 | 0.13 |
Right atrial volume index (ml/m2) | 0.04 ± 0.02 | 6.9 × 10−3 | 0.26 ± 0.07 | 3.0 × 10−4 |
Aorta | ||||
Ascending aortic area index (mm2/m2) | 2.75 ± 0.11 | 4.0 × 10−130 | 2.64 ± 0.50 | 1.5 × 10−7 |
Ascending aortic distensibility (10−3mmHg−1) | −0.09 ± 0.001 | <1 × 10−300 | −0.006 ± 0.005 | 0.22 |
Descending aortic area index (mm2/m2) | 1.86 ± 0.05 | 2.0 × 10−291 | 1.34 ± 0.22 | 2.1 × 10−9 |
Descending aortic distensibility (10−3mmHg−1) | −0.09 ± 0.001 | <1 × 10−300 | –0.02 ± 0.005 | 7.5 × 10−4 |
*Estimates ± SE define coefficients for cardiac and aortic imaging phenotype changes per year age or per doubling of alcohol consumption (g/d) with their standard errors. The aging model was adjusted for sex, ethnicity, body mass index, and prevalence of college degree education, hypertension, diabetes, and smoking history. The alcohol consumption model was adjusted for age, sex, ethnicity, body mass index, and prevalence of college degree education, hypertension, diabetes, and smoking history. SE, standard error.
Alcohol consumption (g/d) in all and males and females for brain grey matter (N = 10,143), brain white matter (N = 9053), heart (N = 11,821), aorta (N = 12,376), and liver (N = 3649).
Coefficients for log2 alcohol and age in an expanded model for cardiac (N = 11,821) and aortic (N = 12,376) imaging phenotypes including tests of interactions between log2 alcohol and age.
STROBE checklist.