Perinatal development of innate immune topology
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), University Medical Center, Faculty of Medicine, University of Freiburg, Germany
- Center for Pediatrics and Adolescent Medicine, University Medical Center, Faculty of Medicine, University of Freiburg, Germany
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Germany
- Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Germany
- CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Germany
- Gut Microbes & Health, Quadram Institute Bioscience, Norwich Research Park, United Kingdom
- Norwich Medical School, University of East Anglia, United Kingdom
- Intestinal Microbiome, School of Life Sciences, and ZIEL - Institute for Food & Health, Technical University of Munich, Germany
- Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University Munich, Germany
- Institute of Medical Microbiology, RWTH University Hospital Aachen, Germany
Figures
Figure 1
Interlinked pre- and postnatal development, adaptation, and maintenance of tissue macrophages.
At birth, tissue MΦ originate from three sources that prenatally seed developing body sites in sequential waves. Postnatally, self-maintenance and renewal by bone marrow-derived monocytes are subject to microanatomical, soluble endogenous and exogenous cues. Establishment of a dynamic, tissue-specific MΦ homeostasis relies on tightly regulated late prenatal and early postnatal events.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Perinatal development of innate immune topology
eLife 10:e67793.
https://doi.org/10.7554/eLife.67793
