1. Immunology and Inflammation

Perinatal development of innate immune topology

  1. Philipp Henneke  Is a corresponding author
  2. Katrin Kierdorf
  3. Lindsay J Hall
  4. Markus Sperandio
  5. Mathias Hornef  Is a corresponding author
  1. Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), University Medical Center, Faculty of Medicine, University of Freiburg, Germany
  2. Center for Pediatrics and Adolescent Medicine, University Medical Center, Faculty of Medicine, University of Freiburg, Germany
  3. Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Germany
  4. Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Germany
  5. CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Germany
  6. Gut Microbes & Health, Quadram Institute Bioscience, Norwich Research Park, United Kingdom
  7. Norwich Medical School, University of East Anglia, United Kingdom
  8. Intestinal Microbiome, School of Life Sciences, and ZIEL - Institute for Food & Health, Technical University of Munich, Germany
  9. Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University Munich, Germany
  10. Institute of Medical Microbiology, RWTH University Hospital Aachen, Germany
https://doi.org/10.7554/eLife.67793
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  1. Philipp Henneke
  2. Katrin Kierdorf
  3. Lindsay J Hall
  4. Markus Sperandio
  5. Mathias Hornef
(2021)
Perinatal development of innate immune topology
eLife 10:e67793.
https://doi.org/10.7554/eLife.67793
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Interlinked pre- and postnatal development, adaptation, and maintenance of tissue macrophages.

At birth, tissue MΦ originate from three sources that prenatally seed developing body sites in sequential waves. Postnatally, self-maintenance and renewal by bone marrow-derived monocytes are subject to microanatomical, soluble endogenous and exogenous cues. Establishment of a dynamic, tissue-specific MΦ homeostasis relies on tightly regulated late prenatal and early postnatal events.

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  1. Philipp Henneke
  2. Katrin Kierdorf
  3. Lindsay J Hall
  4. Markus Sperandio
  5. Mathias Hornef
(2021)
Perinatal development of innate immune topology
eLife 10:e67793.
https://doi.org/10.7554/eLife.67793