The figure shows the averaged whole enrichment curves and their averaged confidence intervals from the bootstrap test, averaged over both iHS and sweep ranks, and over all the populations from each continent (Materials and methods). The y-axis represents the relative sweep enrichment at disease genes, calculated as the number of disease genes in putative sweeps, divided by the number of control non-disease genes in putative sweeps. The gray areas are the 95% confidence interval for this ratio. The number of genes in putative sweeps is measured for varying sweep rank thresholds. For example, at the top 100 rank threshold, the relative enrichment is the number of disease genes within the top 100 genes with the strongest sweep signals (either according to iHS or ), divided by the number of control non-disease genes within the top 100 genes with the strongest sweep signals. We use genes ranked by iHS or using 200 kb windows, since 200 kb is the intermediate size of all the window sizes we use (50 kb, for the smallest, 1000 kb for the largest; see Materials and methods). (A) Africa, average over the ESN, GWD, LWK, MSL, and YRI populations from the 1000 Genomes Project. (B) East Asia, average over the CDX, CHB, CHS, JPT, and KHV populations. (C) Europe, average over the CEU, FIN, GBR, IBS, and TSI populations.