Neural dynamics between anterior insular cortex and right supramarginal gyrus dissociate genuine affect sharing from perceptual saliency of pretended pain
- Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Austria
- Vienna Cognitive Science Hub, University of Vienna, Austria
Figures
Figure 1
fMRI experimental design and behavioral results.
(A) Overview of the experimental design with the four conditions genuine vs. pretended, pain vs. no pain. Examples show static images, while in the experiment participants were shown video clips. (B)…
Figure 2
Neuroimaging results: mass-univariate analyses.
(A) Activation maps of genuine: pain – no pain (top), pretended: pain - no pain (middle), and genuine (pain – no pain) – pretended (pain – no pain) (bottom). As expected, we found brain activations …
Figure 3
DCM results and brain-behavior analyses.
(A) ROIs included in the DCM: aIns (blue; peak: [33, 29, 2]) and rSMG (green; peak: [41, –39, 42]). (B) Posterior probability of modulatory effects for the genuine pain and the pretended pain. (C) …
Tables
Table 1
Results of mass-univariate functional segregation analyses in the MNI space.
| Region label | BA | Cluster size | X | Y | Z | t-value |
|---|---|---|---|---|---|---|
| Genuine: pain - no pain | ||||||
| Lingual_R | 18 | 183,732 | 11 | −84 | −3 | 13.38 |
| Temporal_Pole_Sup_R | 38 | 30 | 33 | −33 | 13.31 | |
| Supp_Motor_Area_R | 8 | 5 | 15 | 51 | 12.96 | |
| Supp_Motor_Area_R | 8 | 3 | 17 | 50 | 12.92 | |
| Supp_Motor_Area_L | 8 | −5 | 17 | 48 | 12.56 | |
| Insula_L | 45 | −32 | 26 | 6 | 12.32 | |
| Insula_R | 45 | 33 | 29 | 3 | 12.09 | |
| Frontal_Inf_Oper_R | 44 | 51 | 14 | 15 | 12.01 | |
| Frontal_Inf_Oper_R | 44 | 50 | 12 | 18 | 11.79 | |
| Precentral_L | 6 | −42 | 3 | 39 | 11.72 | |
| Fusiform_R | 20 | 463 | 36 | −5 | −41 | 5.58 |
| Pretended: pain - no pain | ||||||
| Supp_Motor_Area_R | 8 | 59,665 | 5 | 20 | 48 | 11.80 |
| Supp_Motor_Area_L | 8 | −6 | 18 | 50 | 11.14 | |
| Frontal_Inf_Oper_L | 44 | −50 | 15 | 15 | 10.39 | |
| Insula_R | 45 | 33 | 29 | 0 | 9.81 | |
| Insula_L | 45 | −29 | 30 | 0 | 9.60 | |
| Frontal_Inf_Tri_R | 44 | 47 | 15 | 26 | 9.21 | |
| Precuneus_L | 7 | 35,136 | −9 | −71 | 41 | 10.27 |
| Parietal_Inf_L | 39 | −32 | −51 | 41 | 9.39 | |
| Precuneus_R | 7 | 9 | −69 | 38 | 8.44 | |
| Temporal_Mid_L | 21 | −53 | −47 | 5 | 7.67 | |
| Occipital_Mid_L | 19 | −44 | −78 | 2 | 7.47 | |
| Parietal_Inf_R | 39 | 39 | −50 | 41 | 7.25 | |
| Temporal_Mid_R | 22 | 12,970 | 51 | −20 | –6 | 7.70 |
| Lingual_R | 17 | 12 | −86 | −2 | 7.40 | |
| Fusiform_R | 37 | 47 | −33 | −27 | 5.32 | |
| Occipital_Mid_R | 18 | 33 | −86 | 3 | 5.23 | |
| Cingulum_Mid_R | 23 | 1666 | −3 | −14 | 27 | 6.35 |
| Cingulum_Mid_L | 23 | −3 | −24 | 32 | 5.57 | |
| Temporal_Pole_Sup_R | 47 | 589 | 32 | 35 | −33 | 7.18 |
| Frontal_Sup_Orb_R | 11 | 17 | 41 | −24 | 3.36 | |
| Genuine (pain – no pain) – pretended (pain – no pain) | ||||||
| SupraMarginal_L | 40 | 1877 | −66 | −21 | 32 | 4.94 |
| Postcentral_L | 1 | −50 | −21 | 26 | 3.75 | |
| SupraMarginal_R | 40 | 1833 | 63 | −20 | 42 | 5.09 |
| Rolandic_Oper_R | 40 | 59 | −15 | 14 | 4.47 | |
| Insula_L | 13 | 1299 | −38 | −3 | −2 | 5.01 |
| Rolandic_Oper_L | 4 | −45 | −6 | 8 | 4.8 | |
| Cingulum_Ant_L | 32 | 1138 | 0 | 41 | 17 | 4.54 |
| Cingulum_Mid_R | 32 | 2 | 24 | 32 | 4.45 | |
| Cingulum_Mid_L | 24 | 0 | 2 | 35 | 4.43 | |
| Cingulum_Ant_R | 8 | 2 | 32 | 27 | 4.42 | |
| Lingual_R | 18 | 1003 | 9 | −84 | −3 | 5.72 |
| Calcarine_R | 17 | 18 | −78 | 8 | 3.61 | |
| Insula_R | 13 | 225 | 39 | 8 | −3 | 3.91 |
| Rolandic_Oper_R | 13 | 41 | 0 | 11 | 3.77 | |
Additional files
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Supplementary file 1
Model comparison of linear regression models with three behavioral ratings (independent variables) and the inhibitory effect (dependent variable) for genuine pain and pretended pain.
Smaller AIC/BIC indicates better model fit. Results showed that M1 (without interaction; highlighted with underlining) was the best fitting model for both genuine pain and pretended pain.
- https://cdn.elifesciences.org/articles/69994/elife-69994-supp1-v2.docx
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Transparent reporting form
- https://cdn.elifesciences.org/articles/69994/elife-69994-transrepform1-v2.pdf
