History of winning and hierarchy landscape influence stress susceptibility in mice
- Icahn School of Medicine at Mount Sinai, United States
- Federal University of Santa Catarina, Brazil
Abstract
Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we exposed ranked male and female mice to social and non-social stressors and manipulated social hierarchy position. We found that rank predicts same sex social stress outcomes: dominance in males and females confers resilience while subordination confers susceptibility. Pre-existing rank does not predict non-social stress outcomes in females and weakly does so in males, but rank emerging under stress conditions reveals social interaction deficits in male and female subordinates. Both history of winning and rank of cage mates affect stress susceptibility in males: rising to the top rank through high mobility confers resilience and mice that lose dominance lose stress resilience, though gaining dominance over a subordinate animal does not confer resilience. Overall, we have demonstrated a relationship between social status and stress susceptibility, particularly when taking into account individual history of winning and the overall hierarchy landscape in male and female mice.
Data availability
All data generated or analyzed during this study are included in the manuscript.
Article and author information
Author details
Funding
National Institutes of Health (R01MH114882)
- Scott Russo
National Institutes of Health (R01MH127820)
- Scott Russo
National Institutes of Health (R01MH104559)
- Scott Russo
CAPES-Brazil (Visiting Researcher Fellowship)
- Manuella P Kaster
Canadian Institutes of Health Research (Postdoctoral Fellowship,201811MFE-414896-231226)
- Kenny L Chan
Leon Levy Foundation (Postdoctoral Fellowship)
- Lyonna F Parise
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All animal procedures were approved by the Icahn School of Medicine at Mount SinaiInstitutional Animal Care and Use Committee (Protocol #: LA10-00266 to S.J.R.)
Copyright
© 2021, LeClair et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 2,649
- views
-
- 409
- downloads
-
- 37
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
History of winning and hierarchy landscape influence stress susceptibility in mice
eLife 10:e71401.
https://doi.org/10.7554/eLife.71401
