Insights from full-text analyses of the Journal of the American Medical Association and the New England Journal of Medicine

  1. Moustafa Abdalla  Is a corresponding author
  2. Mohamed Abdalla
  3. Salwa Abdalla
  4. Mohamed Saad
  5. David S Jones
  6. Scott H Podolsky  Is a corresponding author
  1. Harvard Medical School, United States
  2. Department of Statistics, University of Oxford, United Kingdom
  3. Department of Computer Science, University of Toronto, Canada
  4. The Vector Institute for Artificial Intelligence, Canada
  5. University of Bahrain & the Royal Academy, Bahrain
  6. Department of the History of Science, Harvard University, United States
8 figures, 2 tables and 11 additional files

Figures

Time series analyses for the word ‘the’.

(a) Frequency of the word ‘the’ in Journal of the American Medical Association (JAMA), with annual total raw counts (top panel), scaled by article counts (middle panel), and scaled by total number of words (bottom panel). (b) Frequency of the word ‘the’ in New England Journal of Medicine (NEJM), with annual total raw counts (top panel), scaled by article counts (middle panel), and scaled by total number of words (bottom panel).

Time series plots for selected words, with frequency per 100,000 words as a function of year.

Time series plots, with frequency per 100,000 words as a function of year for: the words ‘AIDS’, ‘cancer’, ‘cardiac’, ‘coronavirus’, and ‘tuberculosis’ in the (a) Journal of the American Medical Association (JAMA) corpus (1883–2018) and (b) New England Journal of Medicine (NEJM) corpus (1812–2020); the words ‘autonomy’, ‘consent’, ‘ethical’, ‘ethics’, ‘moral’, ‘professionalism’, and ‘respect’ in (c) JAMA and (d) NEJM; for the words ‘controlled’, ‘experiment’, ‘randomized’, and ‘trial’ in (e) JAMA and (f) NEJM; and for the words ‘clinic’, ‘hospital’, ‘inpatient’, ‘laboratory’, ‘outpatient’, and ‘telephone’ in (g) JAMA and (h) NEJM.

Time series plots for selected bigrams, with frequency per 100,000 bigrams as a function of year.

Time series plots, with frequency per 100,000 bigrams as a function of year, for: the bigram ‘personal equation’ in the (a) New England Journal of Medicine (NEJM) corpus; the bigram ‘antibiotic resistance’ in the (b) Journal of the American Medical Association (JAMA) corpus (1883–2018), and (c) NEJM corpus (1812–2020); the bigram ‘informed consent’ in (d) JAMA and (e) NEJM; the bigram ‘mental retardation’ in (f) JAMA and (g) NEJM; the bigrams ‘health policy’ and ‘managed care’ in (h) JAMA and (i) NEJM; the bigrams ‘breast cancer’ and ‘lung cancer’ in (j) JAMA and (k) NEJM; and the bigrams ‘myocardial infarction’ and ‘heart attack’ in (l) JAMA and (m) NEJM.

Screenshots of our Journal of the American Medical Association (JAMA) and New England Journal of Medicine (NEJM) ngram viewer.

(a) The landing page of our website defaults to the word frequencies highlighted in Figure 3. (b) Analysis functionality includes calculating both the relative and absolute frequencies in both corpora, NEJM only, and JAMA only, as well as plotting cumulative frequencies, changing color of lines to grayscale, and enabling case-sensitive searches. (c) Users can download both the plot as a scalable vector graphics (svg) file and the raw data for their query as a csv file. (d) Frequency lines can be smoothed with the ‘smoothing bar’ on the bottom right-hand corner of the screen. (e) Time series plots can also be limited to a particular window/time period by changing the time bar on the bottom of the screen with the drag-and-drop timeline or with the corresponding dropdown menus.

Time series plot, with frequency per 100,000 words as a function of year, for the word ‘patent’ in the (a) Journal of the American Medical Association (JAMA) corpus and the (b) New England Journal of Medicine (NEJM) corpus.
Time series plot, with frequency per 100,000 words as a function of year, for the word ‘bias’ in the (a) Journal of the American Medical Association (JAMA) corpus and the (b) New England Journal of Medicine (NEJM) corpus.
Evolution of the modern concept of ‘dementia’ as reflected in New England Journal of Medicine (NEJM).

Each column denotes a quarter century: 1900–1924 (yellow), 1925–1949 (green), 1950–1974 (blue-purple), 1975–1999 (pink-violet), and 2000–2020 (red). Clustering using the word addresses/vectors generated during the 2000–2020 groups the following words together: alzheimer, amyotrophic, angiopathy, dementia, frontotemporal, huntington, lewy, lobar, neurodegenerative, neuropathology, parkinson, pick, senile, and wernicke (all highlighted with a red background). We subsequently identify which clusters, historically, each of these 14 terms belonged to. The size of the connections denotes proportionally how many words from that cluster ‘flowed’ into the next. The absence of a connection indicates that two consecutive clusters share no words.

Validation and verification of optical character recognition (OCR) processing of the original New England Journal of Medicine (NEJM) and Journal of the American Medical Association (JAMA) manuscripts.

(a) We estimated the character error rate, to be: 0.26% (± standard deviation [std] = 0.004%; 1 in 384 characters) for articles published before 1899, 0.014% (±std 0.001%; 1 in 7105 characters) for articles published between 1900 and 1949, 0.065% (±std 0.002%; 1 in 1520 characters) for articles published between 1950 and 1999, and 0.037% (±std 0.001%; 1 in 2701 characters) for articles published after 2000. (b) All alphanumeric character discrepancies were traced back to typographical errors introduced by poor printing quality (e.g., e recognized as c when the [horizontal] bar of the letter e is missing). During the manual transcription, we also noted the presence of: (c) typographical errors by the original authors and (d, e) historical word choices.

Tables

Table 1
Table of the 10 most-related terms for the words ‘patent’, ‘abortion’, ‘bias’, ‘defective’, and ‘race’ in Journal of the American Medical Association (JAMA), stratified per decade.

For historical accuracy, we intentionally did not filter misspellings and/or offensive words.

Patent
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
proprietaryproprietaryproprietaryproprietarytrademarkhisteenarteriosusductusductusductusductusductuscoinventorscoinventors
fakishvendersseeretproprictaryproprietaryexploiterductusarteriosusarteriosusarteriosusarteriosusarteriosuscoinventorroyalties
readymadeexploiterproprictaryquackexploiterproprietaryovalecoarctationovalearteriosisduetusforamenovaletherapeutics
mostrumsputentsceretquackerynuritohardproprietaryanomalousarteriosisbcvarteriosisdatabanksforamenbiosimilar
polypharmaceuticfrandulentmostrumnostrumcitrophankolloydarteriosisovaleduetusarteriesovaleinventorspatentscoinventor
bootleggersinventorsdeceptionseeretpatentedwheatquackeryarteriosispostductalduetusperitoneovenousproprietarybiosimilarextensions
proprieproprieexploiterexploitersdistributertrademarkduetustracheoesophagealstenosisgraftsbcvdefectbiosimilarscorevalve
fraudulencerankestfakerexploiterbenetoldistributermedieinesinteratrialarteriesanastomoticarteriesaortopulmonaryclosuresapien
abominationsunblushingquackvendersexploitersnuritostenosisatresiabotalloanastomosiseustachiandevieesndasequity
tisedseeretproprietorshipfakerspurificoexploitersvalvestricuspidbifurcatingcoarctationintraventricularcoinventornonexclusivechimerix
Abortion
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
prematuremiscarriagemiscarriagedeliverymiscarriagemiscarriagemiscarriagemiscarriagepregnancyabortionsabortionscontraceptionabortionsmiscarriage
miscarriagepreviacriminalmiscarriagepregnancyhabitualhabitualcontraceptionabortionspregnancycontraceptionabortionstellinglystillbirth
ectopiclaborpregnancypregnancypuerperalpuerperalahortionpregnancythreatenedeuthanasiapregnancybirtheapenbirth
laborendometritisdeliveryeclampsinahortioncriminalpregnancyahortionintrauterinemidtrimestereuthanasiacriminalizedoffsiteobstetric
uferopregnancylabortubaldeliveryahortionthreatenedhabitualmiscarriageaborectopicconraceptioninfertilityintrauterine
accouchmentectopicectopicinborpregnantstillbirthcriminalabortedcontraceptionlegalmidtrimestermidtrimesterlegalizationspontaneous
deliverypuerperalpraviaahortioncriminalabortionshydatidiformstillbirthinfertilityamniocentesisunwantedsecondtrimestermischaracterizescdmr
faetuseclampsiaeclampsiapuerperalspontaneouspregnancymenorrhagiadeliverylaborcriminaltubaleugenicpregnancypregnancy
hzmorrhagedeliveryprematureprematureeclampsiathreatenedmenstruationthreateneddeliveryunwantedfetussterilizationlegalizingnonlegal
criminalintrauterinepreviaplacentadystociadeliveryectopicabortionspostpartumsterilizationovumamniocentesiscontraceptionpreeclampsia
Bias
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
stigmaguiltinsinceritycondonationprejudicereasoningsprejudiceovergeneralizationbiasesbiasesbiasesbiasesbiasesbiases
beneficencepreferencesprepossessionreasonahleinsincerityargumentationdisadvantageouslyovermatchingprejudiceselectionbiasedbiasedbiasedselection
vilenessinborninstinetsadjudgepretentionstritenessdidacticismuncertaintybiasedovermatchingselectionselectionselectionconfounding
jearningdenialpartisanshipinsincerityprepossessionmarshallingoverloadforeknowledgerepetitionbiasedmisclassificationnondifferentialmisclassificationunmeasured
respomsibilitytrammelsreasoningseruelpartisanshipdidacticismpreconceptionprejudiceerrorsselfselectionnondifferentialselfselectionconfoundingbiased
inflictionsjurymenperversenesspremeditationdepreciatingfairnessselfcenterednonpublicationovermatchingbiasingconfoundingmisclassificationunmeasuredmisclassification
imbuesprepossessiondisinterestednessmeddlesomenessdeludingprejudiceexpectableoversimplificationsgeneralizationgeneralizationovermatchingconfoundingnondifferentialattrition
adherencehypnotizerdiseredituntruthfulnessunreservedadducinghewedartificialityvaliditynonindependenceimprecisionmaskingfunnelblinding
prostitutionmisconstructionerueljurymenindiscriminatingdoctrinairehistrionicsgeneralizationdiscriminationovergeneralizationselfselectionblindingselfselectionvalidity
equityvalidityenthusinsmtactlessunkindlyimpressivenessneutrallyinterpretationalpreferencesoversimplificationsunderreportingmisreportingimprecisionimprecision
Defective
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
calorificationimpairedimpaireddefectsdefectsmentallyimpairedimpairedimpairedchemotaxiseukaryoticmutantmitochondriatlr1
deficiencydefectsimperfectdefectimpaireddefectsdefectsdefectsfibrinasedefectdefectribozymecftrautophagy
malnutritionmalnutritiondefectsdefeetspoorpoorcongenitallyretardationabnormalimpairedmitochondrialfaslmitochondrialpvhl
abnormalitiesimperfectdeficiencypoormentallydefectabnormalcongenitallydefectglycosphingolipidprogenitorgermlineautophagycardiomyocyte
nilretardationdeficienciesmentallyabnormalcongenitallyretardationdefectrecessivelysuppressormutantgeneticallyryanodinecd47
imperfectdefectabnormalabnormalitiescongenitallycardiopathicmentallymentallyprtaseantiglomerularclonederegulatedpvhltlr2
impairmentnutritiondefectabnormaldefectidiotcardiopathicabnormalneurovisceralfibrinaseretroviraloncogenemisfoldedmfn2
deciduouscongenitallyimperfectimpairedcardiopathicaberrationsunstableimpairmentcongenitallymitochondrialgeneticallyphenotypesod1hmga1
emotionalimpairmentmentallyinsuflicientimpairmentoffspringblindpoordeficiencyleukotacticgenefibrillinmutanttxnip
immobilitydisturbancesanomaliesmalnutritiondeafmutesimpairedpoordeficiencyheterozygoticneurofilamentchaperonedeletiondegradationmapk
Race
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
happinessoffspringnegrocommunityracessexsexsexsexsexsexethnicityethnicityethnicity
offspringpeopleshumansexnativeracesnationalityethnicnationalityageethnicsexsexsex
intellectualhappinessancestrynegropeoplesancestrygeographicancestryethnicmaritalmaritalgendergenderhispanic
fetichismafricanmankindsocialancestryethniccreednationalitygeographicnativitygendermaritalethnicage
religionancestryhereditaryhumandominantjewsnativitynativitymaritalethnicethnicityagestatusmarital
bruteshybridpeoplesmoralrecessivenationalitymaritalnegroidnativityreligionagestatusselfidentifiedstatus
populationsinstinctuncivilizedhereditarysexhereditarynegromaritalgeographybirthdatereligionnicityhispanicorigin
tenderestesquimauxdegeneracyoffspringpopulationsintermarriagehappinessmatingagesmokinghispanicselfidentifiedageselfidentified
moralsreligionzoophilismsocinlcommunityfamilyindianstemperamenthabitssociceconomiccharacteristicshispaniesociodemographicasian
gamblingmankindraceseugeniesinterbreedingtabusagegeographicreligiondistributionsociceconomichispanicmaritaldemographics
  1. Notes: All 200 most-related terms are available in Supplementary files.

Table 2
Table of the 10 most-related terms for the words ‘patent’, ‘abortion’, ‘bias’, ‘defective’, and ‘race’ in New England Journal of Medicine (NEJM), stratified per decade.

Given space constraints and to facilitate comparison with Table 1, we limit the tables to post-1880s; full analyses (1810–2020) are provided in eTables. For historical accuracy, we intentionally did not filter misspellings and/or offensive words.

Patent
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
compounderrevalentaproprietaryproprietaryductusarteriosusductusductusductusductusductusarteriosusforamenovale
peddlingproprietaryquackquackarteriosusductusarteriosusarteriosusarteriosusarteriosusarteriosusductusovaleforamen
revalentavendersrevalentaquackeryeommonovaleovaleovaleovaleovalelicensingforamenductusamplatzer
affixingwholesalereommonmagnanarroavincompetencetranspositiontetralogyforamensaphenousarteryovalecoinventorsductus
fouledrummagevenderscorearteriosasarteriosasseptalforameninteratrialarteriescavaamplatzerarteriosusarteriosus
baitedquackblameworthythyroglossalovaletruncusbicuspidfallottruncusgraftspdaoccluderamplatzerdevice
rummagehawkersrummageclusterpapillatricuspidcoarctationarteriesdextrocardiaforamenequityinfarctrelatedinventorscorevalve
vulcanizedcompounderleakappendageunsafeseptalinterauriculartruncusstenosisstenosisventriculoamnioticstarflexcoinventorcoinventors
utensiltðpeloaffixingmedicinaltighturachusarteriosasdilatedtoleftatresialefttoanomalouspatentspatents
vendersvendingshellfishdangerofevilvalvesstenosisinteratriallefttocoarctationamplatzervenosuspfocoinventor
Abortion
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
prematuremiscarriagemiscarriageeetopicmiscarriagemiscarriagethreatenedmiscarriagepregnancyabortionsabortionsmiscarriageabortionssterilization
miscarriagecriminaltubaljustifiabilityectopicpregnancyintrauterinehabitualsepticpregnancymiscarriageabortionsmiscarriagecontraception
deliverysepsisprematureeclampsiaeclampsiatubalmiscarriagestillbirthplacentaecontraceptionstillbirthcontraceptionsterilizationlabor
threatenedprematureectopictubaleetopicintrauterinehabitualplacentaeabruptioeuthanasiapregnancylegalizationmifepristoneunwanted
eclampsiapuerperalsepsisdivorcesepticemiaplacentaestillbirthpregnancystillbirthsterilizationinfertilitypregnancypregnancyrefusal
subinvolutionpregnancydeliverypostpartumablatiopreviapuerperaltubaltoxemiaamniocentesisfirsttrimesterassistedstillbirthabortions
replacementeclampsiapregnancyintrauterinepreviapregnaneytoxemiaabortionslaborfetusabortedsterilizationlabormarriage
pregnancytubalcriminalthreatenedaccidentalaccretapreviaabruptiocontraceptionmidtrimestercontraceptionmifepristonelegalizationreligious
menorrhagiaendometritisfetusmiscarriagepostpartumectopicpregnancyhyperemesisfetusunwantedtubalunwantedbendectincouples
pregnaucypreviapreviaprseviatoxemiatoxemiatubalpraeviaabortionsstillbirthfetuslegalmultifetalconscience
Bias
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
denialaggressiveinsincerityavowaldeceptionmisconstructionmisjudgmentnonexistenceprejudicebiasesbiasesbiasesmisclassificationbiases
jurymanprepossessionsinfulnesseriticsymbolicfairmindedprocrastinationprejudicepervasivemisclassificationbiasedmisclassificationbiasesmisclassification
unwisdomconscienceunwisdomexpositorinbornblindeddiscriminationprovableoverenthusiasmbiasedmisclassificationbiasedconfoundingselection
scoffingfairnesscarclessnesscarnestlyguiltverbalpessimismsubjectivitygeneralizationselectionbiasingselectionbiasedbiasing
consciencerepressionunmanlyconvietionconsciencebroadmindedmisconceptiongeneralizationhunchesbiasingselectionconfoundingselectionbiased
prudishdenialbiassedscoffinginsinceritydisavowalgrudgesdenialbiasesprejudiceimprecisionnondifferentialnondifferentialconfounding
jealousyslovenlinessunsettlewitticismsubconsciousecriticismdepreciatoryfantasyundocumentedimprecisionnondifferentialoverreportingbiasingnondifferential
excusingforbearingmetaphysicalecriticismintolerantmisjudgmentgynicdenigrationsubjectivityretrospectiveblindingbiasingunderpowerednonresponse
impoliticvindictivenessdeprecationrecreantmalevolencedogmatizeshirksincongruitiesinjusticesproblemrepresentativenessdesignoverreportingattrition
impietydisabuseddispossessdispossesssinfulnessindelicacycomprehensionmisjudgmentdenialnondifferentialgeneralizationascertainmentnonresponseblinding
Defective
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
defectsimpaireddefectsmentallydefectsretardationunbalanceimpairedimpairedimpaireddefectexpressiondysregulatednlrp3
defectplumbingunstabledefectsmentallydefectsregulatorygermdeficiencydefectimpairedconstitutiverepressionsenescence
overcrowdingdefectdefeetivedefectmalnutritionimpairedmaladjustedacceleratedcongenitallydeficiencypretranslationalalas2nlrp3dysregulated
plumbingdefeetivedefectfeeblemindeddefectdisorderantisocialaberrationphenotypetuftsinactivationgenesmad3dock2
excrementalaerialdeficiencydeficiencyimpaireddeformitiesunstableerythropoieticabnormalabnormalglucosylationbcl11batg5mitophagy
sybtemdefectivoimpaireddelinquentsadultscongenitallylackofmaskinghexosephosphatedisordertuftsinphagocytestat5brepression
defectivoovercrowdingcongenitallydefectivesdelinquentsmentallyimpotencedefectimpairmentgeneticallypostreceptormosaicorai1aberrant
storagemalformationdeteriorationimbecilesincorrigibilitydentitionhyperactivitydeficiencyacceleratedsialyltransferaseperoxisomestransactivatingopa1ikk2
defeetivedefectsbackwardnessmoronblindcrowdingconditioningcongenitallymetabolicallyaberrationaberrantdownregulateunderexpressiongata3
impairmentdeteriorationabnormalitiesdelinquentvisionmalnutritiongermplasmdeficienciesreutilizeddepressedgalactosylationorganellesupregulatedIκBα
Race
1880–18891890–18991900–19091910–19191920–19291930–19391940–19491950–19591960–19691970–19791980–19891990–19992000–20092010–2019
peoplesnegrojewsnegrohappinessjewssexsexsexsexsexethnicethnicethnic
anglosaxonbeautyoffspringextinctionpeoplesreligionclimatemaritalethnicethnicethnicsexsexsex
uncivilizedyouthyouthpeoplesjewsnegroadolescentnationalityreligionreligionageethnicityhispanichispanic
savageryancestrypeoplesuncivilizedachievementracestraitethnicnationalitymaritalsociocconomicmaritalethnicityethnicity
offspringsocialintellectualcivilizationreligionpopulationsgeneticnativitymaritalnationalityurbanizationhispanicnonblackasian
religionapebarbarianreligionhabitatdominantenvironmentalreligionpaternalmarriagetadjustedsociodemographicmaritalfemale
syphilizedhumauweaklingsweaklingsamericanspatriarchalreligionscxspouseshabitsgendernonblacknonwhitemarital
debauchednativesuncivilizedanglosaxonyouthinheritedcreeddistributionstatussociocconomicscxparityblackself
warlikepeopleslearninginnatepovertyjewishdivorcetraitnunsnativityethnicitysociocconomicstatusmale
negrosportslovematingintellectualanglosaxonstatusporulationpartnersminoritiesmaritalnonwhitenonhispanicstatus
  1. Notes: All 200 most-related terms are available in Supplementary files.

Additional files

Supplementary file 1

Table of the 200 most-related terms for the word ‘patent’ in Journal of the American Medical Association (JAMA), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp1-v1.xlsx
Supplementary file 2

Table of the 200 most-related terms for the word ‘patent’ in New England Journal of Medicine (NEJM), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp2-v1.xlsx
Supplementary file 3

Table of the 200 most-related terms for the word ‘abortion’ in Journal of the American Medical Association (JAMA), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp3-v1.xlsx
Supplementary file 4

Table of the 200 most-related terms for the word ‘abortion’ in New England Journal of Medicine (NEJM), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp4-v1.xlsx
Supplementary file 5

Table of the 200 most-related terms for the word ‘bias’ in Journal of the American Medical Association (JAMA), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp5-v1.xlsx
Supplementary file 6

Table of the 200 most-related terms for the word ‘bias’ in New England Journal of Medicine (NEJM), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp6-v1.xlsx
Supplementary file 7

Table of the 200 most-related terms for the word ‘defective’ in Journal of the American Medical Association (JAMA), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp7-v1.xlsx
Supplementary file 8

Table of the 200 most-related terms for the word ‘defective’ in New England Journal of Medicine (NEJM), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp8-v1.xlsx
Supplementary file 9

Table of the 200 most-related terms for the word ‘race’ in Journal of the American Medical Association (JAMA), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp9-v1.xlsx
Supplementary file 10

Table of the 200 most-related terms for the word ‘race’ in New England Journal of Medicine (NEJM), stratified per decade.

https://cdn.elifesciences.org/articles/72602/elife-72602-supp10-v1.xlsx
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  1. Moustafa Abdalla
  2. Mohamed Abdalla
  3. Salwa Abdalla
  4. Mohamed Saad
  5. David S Jones
  6. Scott H Podolsky
(2022)
Insights from full-text analyses of the Journal of the American Medical Association and the New England Journal of Medicine
eLife 11:e72602.
https://doi.org/10.7554/eLife.72602