Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
- University of Edinburgh, United Kingdom
Abstract
Complementary actions of the neocortex and the hippocampus enable encoding and long-term storage of experience dependent memories. Standard models for memory storage assume that sensory signals reach the hippocampus from superficial layers of the entorhinal cortex (EC). Deep layers of the EC on the other hand relay hippocampal outputs to the telencephalic structures including many parts of the neocortex. Here we show that cells in Layer 5a of the medial EC send a copy of their telencephalic outputs back to the CA1 region of the hippocampus. Combining cell-type specific anatomical tracing with high-throughput RNA-sequencing based projection mapping and optogenetics aided circuit mapping, we show that in the mouse brain these projections have a unique topography and target hippocampal pyramidal cells and interneurons. Our results suggest that projections of deep medial EC neurons are anatomically configured to influence the hippocampus and neocortex simultaneously and therefore lead to novel hypotheses on the functional role of the deep EC.
Data availability
On publication data and analysis scripts will be made publicly available via University of Edinburgh's Datashare service (http://datashare.is.ed.ac.uk/). This is an online data repository maintained by the University. MAPseq data will be made available at NLM Sequence Read Archive BioProject.
Article and author information
Author details
Funding
Wellcome Trust (211236/Z/18/Z)
- Gulsen Surmeli
Royal Society (211236/Z/18/Z)
- Gulsen Surmeli
Biotechnology and Biological Sciences Research Council (BB/M025454/1)
- Christina McClure
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All animal experiments were approved by the University of Edinburgh animal welfarecommittee and were performed under a UK Home Office project license.
Copyright
© 2022, Tsoi et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
Metrics
-
- 3,001
- views
-
- 422
- downloads
-
- 16
- citations
Views, downloads and citations are aggregated across all versions of this paper published by eLife.
Download links
A two-part list of links to download the article, or parts of the article, in various formats.
Downloads (link to download the article as PDF)
Open citations (links to open the citations from this article in various online reference manager services)
Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)
Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
eLife 11:e73162.
https://doi.org/10.7554/eLife.73162
