(A) Mice body weight throughout the experiment. The X-axis indicates the age of mice. (B) Schematic representation of tissue weight. (C) Plasmatic triacylglycerol (TAG) levels at week 16 after streptozotocin (STZ) injection. (D–F) Representative bright-field images of whole kidney sections (E) and cortex magnification (D) stained with Oil Red O (ORO). Quantification of the stained cortex area (F). Scale bars: 50 μm. (G) Plasmatic LCN2 levels at week 12 after STZ injection. (H, I) Representative bright-field images of kidney cortex stained with Picro-Sirius Red (H) and the quantification of the fibrotic cortex area (I). Scale bars: 50 μm. (J) Fibrotic area detected by Picro-Sirius Red normalized by fat deposition measured by ORO in mouse kidney cortex. (K) Quantitative RT-PCR detection of Ccl5 and Fn-1 expression levels in mouse kidney cortex. In (A, C, G, I–K), data are presented as mean ± SEM. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001; one-way ANOVA plus Holm–Sidak’s multiple comparisons test. In (B), data are presented as mean ± standard deviation. *p<0.05, **p<0.01, ****p<0.0001 vs. Ctl; #p<0.05 vs. Ctl diet + STZ; one-way ANOVA plus Holm–Sidak’s multiple comparisons test. (A–C, F, G, I, J, K), n = 7Ctl diet, n = 8Ctl diet + STZ, n = 8 MUFA-HFD+ STZ, n = 7 SFA-HFD+ STZ.