Audiovisual task switching rapidly modulates sound encoding in mouse auditory cortex

  1. Ryan James Morrill
  2. James Bigelow
  3. Jefferson DeKloe
  4. Andrea R Hasenstaub  Is a corresponding author
  1. University of California, San Francisco, United States

Abstract

In everyday behavior, sensory systems are in constant competition for attentional resources, but the cellular and circuit-level mechanisms of modality-selective attention remain largely uninvestigated. We conducted translaminar recordings in mouse auditory cortex (AC) during an audiovisual (AV) attention shifting task. Attending to sound elements in an AV stream reduced both pre-stimulus and stimulus-evoked spiking activity, primarily in deep layer neurons and neurons without spectrotemporal tuning. Despite reduced spiking, stimulus decoder accuracy was preserved, suggesting improved sound encoding efficiency. Similarly, task-irrelevant mapping stimuli during intertrial intervals evoked fewer spikes without impairing stimulus encoding, indicating that attentional modulation generalized beyond training stimuli. Importantly, spiking reductions predicted trial-to-trial behavioral accuracy during auditory attention, but not visual attention. Together, these findings suggest auditory attention facilitates sound discrimination by filtering sound-irrelevant background activity in AC, and that the deepest cortical layers serve as a hub for integrating extramodal contextual information.

Data availability

Physiology and behavior data supporting all figures in this manuscript have been submitted to Dryad with DOI: 10.7272/Q6BV7DVM

The following data sets were generated

Article and author information

Author details

  1. Ryan James Morrill

    Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-8592-4549
  2. James Bigelow

    Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States
    Competing interests
    The authors declare that no competing interests exist.
  3. Jefferson DeKloe

    Coleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. Andrea R Hasenstaub

    oleman Memorial Laboratory, University of California, San Francisco, San Francisco, United States
    For correspondence
    andrea.hasenstaub@ucsf.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3998-5073

Funding

National Institutes of Health (R01NS116598)

  • Andrea R Hasenstaub

National Institutes of Health (R01DC014101)

  • Andrea R Hasenstaub

National Science Foundation (GFRP)

  • Ryan James Morrill

Hearing Research Incorporated

  • Andrea R Hasenstaub

Klingenstein Foundation

  • Andrea R Hasenstaub

Coleman Memorial Fund

  • Andrea R Hasenstaub

National Institutes of Health (F32DC016846)

  • James Bigelow

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Brice Bathellier, CNRS, France

Ethics

Animal experimentation: All experiments were approved by the Institutional Animal Care and Use Committee at the University of California, San Francisco.

Version history

  1. Preprint posted: November 11, 2021 (view preprint)
  2. Received: November 24, 2021
  3. Accepted: August 17, 2022
  4. Accepted Manuscript published: August 18, 2022 (version 1)
  5. Version of Record published: August 30, 2022 (version 2)

Copyright

© 2022, Morrill et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Ryan James Morrill
  2. James Bigelow
  3. Jefferson DeKloe
  4. Andrea R Hasenstaub
(2022)
Audiovisual task switching rapidly modulates sound encoding in mouse auditory cortex
eLife 11:e75839.
https://doi.org/10.7554/eLife.75839

Share this article

https://doi.org/10.7554/eLife.75839

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