Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making
- Brandeis University, United States
Abstract
Memory-guided decision making involves long-range coordination across sensory and cognitive brain networks, with key roles for the hippocampus and prefrontal cortex (PFC). In order to investigate the mechanisms of such coordination, we monitored activity in hippocampus (CA1), PFC, and olfactory bulb (OB) in rats performing an odor-place associative memory guided decision task on a T-maze. During odor sampling, the beta (20-30 Hz) and respiratory (7-8 Hz) rhythms (RR) were prominent across the three regions, with beta and RR coherence between all pairs of regions enhanced during the odor-cued decision making period. Beta phase modulation of phase-locked CA1 and PFC neurons during this period was linked to accurate decisions, with a key role of CA1 interneurons in temporal coordination. Single neurons and ensembles in both CA1 and PFC encoded and predicted animals' upcoming choices, with different cell ensembles engaged during decision-making and decision execution on the maze. Our findings indicate that rhythmic coordination within the hippocampal-prefrontal-olfactory bulb network supports utilization of odor cues for memory-guided decision making.
Data availability
Data is available for download on figshare:Data DOI: https://doi.org/10.6084/m9.figshare.19620783.v1
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Rhythmic coordination of hippocampal-prefrontal ensembles for odor-place associative memory and decision makingfigshare, DOI: 10.6084/m9.figshare.19620783.v1.
Article and author information
Author details
Funding
National Institute of Mental Health (R01MH120228)
- Shantanu P Jadhav
National Institute of Mental Health (R01MH112661)
- Shantanu P Jadhav
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All experimental procedures were approved by the Brandeis University InstitutionalAnimal Care and Usage Committee (IACUC) and conformed to US National Institutes of Health. Procedures were approved under IACUC Protocol # 21001
Copyright
© 2022, Symanski et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making
eLife 11:e79545.
https://doi.org/10.7554/eLife.79545
