State dependent coupling of hippocampal oscillations
- European Brain Research Institute, Italy
- Radboud University Nijmegen, Netherlands
Abstract
Oscillations occurring simultaneously in a given area represent a physiological unit of brain states. They allow for temporal segmentation of spikes and support distinct behaviors. To establish how multiple oscillatory components co-varies simultaneously and influence neuronal firing during sleep and wakefulness in mice, we describe a multi-variate analytical framework for constructing the state space of hippocampal oscillations. Examining the co-occurrence patterns of oscillations on the state space, across species, uncovered the presence of network constraints and distinct set of cross-frequency interactions during wakefulness as compared to sleep. We demonstrated how the state space can be used as a canvas to map the neural firing and found that distinct neurons during navigation were tuned to different sets of simultaneously occurring oscillations during sleep. This multivariate analytical framework provides a window to move beyond classical bivariate pipelines, for investigating oscillations and neuronal firing, thereby allowing to factor-in the complexity of oscillation-population interactions.
Data availability
Datasets used in this study are available at Crcns.org (HC11 dataset) and Donders Repository (https://data.donders.ru.nl/collections/di/dcn/DSC_62002873_05_861)All codes are available made at https://github.com/brijeshmodi12/network_state_space
Article and author information
Author details
Funding
European Union Horizon 2020 research and innovation program MGATE (765549)
- Francesco P Battaglia
European Union Horizon 2020 research and innovation (840704)
- Federico Stella
ERC Advanced Grant (833964)
- Francesco P Battaglia
Telethon (GGP16083)
- Enrico Cherubini
Del Monte Foundation
- Enrico Cherubini
EMBO short term fellowship (8464)
- Brijesh Modi
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: In compliance with Dutch law and institutional regulations, all animal procedures concerningrecordings from freely moving or sleeping mice were approved by the Central Commissie Dierproeven(CCD) and conducted in accordance with the Experiments on Animals Act (project number 2016-014and protocol numbers 0029).All experiments from head-restrained animals were performed in accordance with the Italian AnimalWelfare legislation (D.L. 26/2014) that implemented the European Committee Council Directive(2010/63 EEC) and were approved by local veterinary authorities, the EBRI ethical committee, andthe Italian Ministry of Health (565/PR18) All efforts were made to minimize animal suffering and toreduce the number of animals used
Copyright
© 2023, Modi et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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State dependent coupling of hippocampal oscillations
eLife 12:e80263.
https://doi.org/10.7554/eLife.80263
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