(A) Resting image of two partially overlapping simulated cells (left) and regions of interest (ROIs) used for analysis (right). bg – background. (B) ΔF template of cell 1. (C) Top, simulated trains …
Numerical data presented in Figure 1.
(A) Sample D(t) traces (top) and raster plots showing reconstructed Ca2+ transient (CaT) onsets (bottom). Note the developmental transition from discontinuous to continuous network activity. (B) …
Numerical data presented in Figure 2.
(A) Sample traces of the fraction of active cells Φ(t). Gray and orange bars indicate discontinuous and continuous network activity, respectively. Bottom traces show time periods marked on top …
Numerical data presented in Figure 3.
(A) Total time spent in NBs (left), mean NB duration (middle), and mean NB size (right) as a function of the parameter Δt. Δt was used for computing a Ca2+ transient (CaT) frequency-dependent …
Numerical data presented in Figure 3—figure supplement 1.
(A) The mean PopC index peaked at P11. (B) Mean fraction of cells with significant PopC. (C) Mean PopC index of significantly coupled cells only. (D) Sample spike-time tiling coefficient (STTC) …
Numerical data presented in Figure 4.
(A) Similarity matrices (matching index) of binary activity patterns (re-ordered for illustration of motif detection) from three individual fields of view (FOVs) at P4, P11, and P18. (B) Global …
Numerical data presented in Figure 5.
(A) Sample respiration/movement signal from an individual mouse receiving either 75% N2O/25% O2 (top) or pure O2 (Unanesth., bottom). Detected movement periods are highlighted. (B) Respiration rate …
Numerical data presented in Figure 6 and Figure 6—figure supplement 2.
(A and B) Sample respiration/movement signal (middle) and time-aligned spectrogram (bottom; 0.5–20 Hz, window length: 1 s, overlap: 50%) used to detect movement periods, respiration, and heart rate. …
(A) Experimental timeline. In each animal, two fields of view (FOVs) were recorded with and without N2O (paired design). (B) Rasterplots (top) and time-aligned fraction of active cells Φ(t) (bottom) …
(A) Schematic diagram of the short-term synaptic plasticity (STP)-recurrent neural network (RNN) model. (B) The of the full STP-RNN’s stationary dynamics. Note the presence of two stable fixed …
(A–C) Input delivered to the network before the deadline can move it to active state. (A) A successful transition. The input delivered at t = 0.8 s; , . (B) The of the short-term synaptic …
(A–H) Same format as in Figure 8. Following the failure of the network in transitioning to the active state due to missing the deadline (dotted black line #1, at t = 1.45 s), the subsequent input …
(A) The inhibition-stabilized network (ISN) regime becomes accessible to the network upon the developmental emergence of synaptic inhibition. The colored regions in each of the network model …
(A) In contrast to the bi-stable STP-RNN, Mono-RNNi and Mono-RNNe networks lack a silent state (i.e. a fixed point [FP] at origin). Same format as Figure 9A, overlaid by the (red), the (blue), …
Reagent type (species) or resource | Designation | Source or reference | Identifiers | Additional information |
---|---|---|---|---|
Strain and strain background (Mus musculus) | B6.129S2-Emx1tm1(cre)Krj/J (Emx1IREScre) | The Jackson Laboratory | RRID: IMSR_JAX:005628 | |
Strain and strain background (Mus musculus) | B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J (Rosa26LSL-GCaMP6s) | The Jackson Laboratory | RRID: IMSR_JAX:024106 | |
Software and algorithm | Wolfram Mathematica 13 | Wolfram | RRID:SCR_014448 | |
Software and algorithm | Matlab 2021b | Mathworks | RRID:SCR_001622 | |
Software and algorithm | Fiji | PMID:22743772 | RRID:SCR_002285 | |
Software and algorithm | Calcium transient detection harnessing spatial similarity (CATHARSiS) | This paper | N/A | https://github.com/kirmselab/CATHARSiS |
Statistical tests used in this study.
(a) Synopsis of statistical tests related to Figure 1. Numerical data are provided in the Figure 1—source data 1. (b) Synopsis of statistical tests related to Figure 2. Numerical data are provided in the Figure 2—source data 1. (c) Synopsis of statistical tests related to Figure 3. Numerical data are provided in the Figure 3—source data 1. (d) Synopsis of statistical tests related to Figure 4. Numerical data are provided in the Figure 4—source data 1. (e) Synopsis of statistical tests related to Figure 5. Numerical data are provided in the Figure 5—source data 1. (f) Synopsis of statistical tests related to Figure 6 and Figure 6—figure supplement 2. Numerical data are provided in the Figure 6—source data 1.