Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations
- Department of Bionanoscience, Delft University of Technology, Netherlands
- Kavli Institute of Nanoscience, Netherlands
- Fagenbank, Netherlands
Figures
Figure 1 with 1 supplement
Phage transfer RNAs (tRNAs) are predicted to be anticodon nuclease resistant.
(A) The genomic context of the tRNA clusters containing 36 tRNAs present in C1 mycobacteriophage Rizal (Russell and Hatfull, 2017). (B) Prevalence of individual phage-encoded tRNAs in the C1 …
Figure 1—figure supplement 1
Phage transfer RNAs (tRNAs) from enterobacteria.
(A) Mutations in the anticodon loop of phage tRNAs in comparison to host tRNAs, located in the cleavage site of anticodon nucleases of tRNA fMet (cat) that are targeted by VapCs. (B) Mutations in …
Additional files
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Supplementary file 1
Phage versus host-encoded transfer RNA (tRNA) comparisons.
(a) Overview of all C1 mycobacteriophage encoded tRNAs. (b) Overview of anticodons encoded by C1 mycobacteriophages compared to their hosts'. (c) Analysis of anticodon loop mutations and anticodon avoidance in other species.
- https://cdn.elifesciences.org/articles/85183/elife-85183-supp1-v2.xlsx
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MDAR checklist
- https://cdn.elifesciences.org/articles/85183/elife-85183-mdarchecklist1-v2.docx
