Stochastic characterization of navigation strategies in an automated variant of the Barnes maze
- Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology (KIST), Republic of Korea
- Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Republic of Korea
Figures
Figure 1 with 1 supplement
Design and operation of the automated variant of the Barnes maze.
(a) Scheme (left) and picture (right) showing a side view of the apparatus with its different components. The environmental cues are restricted to objects within the arena as the tinted cover blocks …
Figure 1—figure supplement 1
Detailed view of the automated variant of the Barnes maze.
(a–c) Pics of the entire apparatus (a) and of the side (b) and top views (c) of the apparatus. (d) Zoom on the side doors. (e–f) Zoom on the inside of one of the home boxes. (g–h) Side view of one …
Figure 2 with 4 supplements
Statistical characterization of vestibule sequences across days.
(a) Top view of the maze (left) and two example trajectories on top of an overlay of multiple trajectories (right) showing vestibules and trajectory segmentation. The goal is at vestibule 0. Running …
Figure 2—figure supplement 1
Statistical characterization of vestibule sequences across days, for male and female separately.
(a) The average path length as a function of segment size across the 15 training days and 4 reversal days (color coded) and averaged across day 6–15 (lines) for male and female separately. (b–e) …
Figure 2—figure supplement 2
Path length and number of segments per trial across days.
(a) Average path length per trial across days, for male (left) and female (right). (b) Average number of segments per trial across days, for male (left) and female (right). (mean ± standard …
Figure 2—figure supplement 3
Quadrant and vestibule preference during the probe test.
(a) Fraction of time spent in each quadrant of the arena during the probe test, for male (blue), female (red), and all mice (black). (b) Fraction of time spent in each vestibule during the probe …
Figure 2—figure supplement 4
Vestibule orientation determines the direction of serial behavior.
(a) Top view of the arena (upper) and distribution of segment sizes (lower) for a leftward orientation of vestibules (red arrow). (b) Same as (a) for a rightward orientation of vestibules. Notice …
Figure 3 with 1 supplement
Statistical characterization of vestibule sequences across trials.
(a) The average path length as a function of segment size for 2 time periods capturing the dynamic range of the distributions (lines) and across trials (color coded). The data from days 6 to 15 were …
Figure 3—figure supplement 1
Statistical characterization of vestibule sequences across trials, for male and female separately.
(a) The average path length as a function of segment size across trials (color coded) and averaged across trials (lines) for male and female separately. The data from days 6 to 15 were used for this …
Figure 4
Stochastic processes for random, spatial and serial strategies.
(a) Schemes describing the stochastic processes for random, spatial and serial strategies. Vi +1: the next vestibule visited; Vi: the current vestibule; S: the next segment (a number of …
Figure 5 with 2 supplements
Mixture model fitting of strategy evolution across days.
(a) Mixture model combining the stochastic processes associated with random, spatial and serial strategies. A vestibule sequence is generated in two alternating steps. In step 1, a strategy is drawn …
Figure 5—figure supplement 1
Strategy evolution across days based on the mixture model fit.
(a) Fits of experimental distributions across the 15 training days and 4 reversal days, using the mixture model and a strategy draw occurring every N=6 segments. Color coded, mean square error …
Figure 5—figure supplement 2
Inter-animal variations in search strategy across days.
(a) Proportions of each strategy across days for individual animal, obtained from the best fits of the mixture model. (b) Average proportions of each strategy across male (upper left), female (lower …
Figure 6
Markov chain modeling of within-trial strategy evolution.
(a) Markov chain model incorporating four strategies (random, serial clockwise, serial counterclockwise and spatial). To generate vestibule sequences, the model iteratively draws a strategy and then …
