Task-specific invariant representation in auditory cortex
- Neuroscience Graduate Program, Oregon Health and Science University, United States
- Otolaryngology, Oregon Health & Science University, United States
Figures
Figure 1 with 1 supplement
Tone-in-noise detection behavior.
(a) Schematic of go/no-go tone-in-noise detection task. Licking responses to target tones were rewarded, while responses to narrowband noise distractors were penalized with a timeout. Target tone …
Figure 1—figure supplement 1
Behavioral performance of individual animals.
Cumulative reaction time histogram for each animal and target sound across all behavior sessions. Color indicates sound identity. Animals were rewarded for responses to all sounds except the catch.
Figure 2 with 4 supplements
State-dependent modulation of single neuron target vs. catch discrimination.
(a) Example peristimulus time histogram (PSTH) responses from a single recording site in A1. Heatmap color in each row indicates the PSTH amplitude of one neuron. Dashed lines indicate sound …
Figure 2—figure supplement 1
Penetration map for one example animal.
Left hemisphere from one animal. Each marker indicates the anatomical location of a single electrode penetration. Color indicates the average best frequency (BF) of neurons recorded at each location …
Figure 2—figure supplement 2
State-dependent modulation of singe neuron target vs. catch discrimination in dPEG.
(a) Example peristimulus time histogram (PSTH) responses from a single recording site in dPEG. Heatmap color in each row indicates the PSTH amplitude of one neuron. Dashed lines indicate sound …
Figure 2—figure supplement 3
Single neuron target vs. catch raster plots for all A1 recording sites.
Example peristimulus time histogram (PSTH) responses from all recording sites in A1. Each group of six panels corresponds to a single recording site, as in Figure 2. Heatmap color in each row of …
Figure 2—figure supplement 4
Single neuron target vs. catch raster plots for all dPEG recording sites.
Example peristimulus time histogram (PSTH) responses from all recording sites in dPEG. Each group of six panels corresponds to a single recording site, as in Figure 2. Heatmap color in each row of …
Figure 3 with 2 supplements
Selective enhancement of task-relevant category representation in the secondary auditory cortex.
(a) Left: Representative A1 population activity during passive listening projected into a two-dimensional space optimized for discriminating target versus catch responses. Each dot indicates the …
Figure 3—figure supplement 1
Pupil dynamics reflect both generalized arousal as well as trial outcome.
(a) Top: Histogram of pupil size across all experiments (n=39 sessions, n=4 animals) during active (orange) and passive (blue) trials. Pupil size is normalized to the max pupil size observed within …
Figure 3—figure supplement 2
Selective enhancement of task-relevant category representation in the secondary auditory cortex is not affected by global arousal.
Same as in Figure 3, without first correcting for pupil-indexed arousal explainable variance (i.e. decoding stimulus identity from raw neural activity, without controlling for global arousal). (a) …
Figure 4 with 1 supplement
Changes in neural decoding are correlated with behavior performance in dPEG, but not A1.
(a) Scatter plot compares neural Δd-prime (active minus passive) for all tone-in-noise target vs. catch noise combinations against the corresponding behavioral d-prime for that target vs. catch …
Figure 4—figure supplement 1
Choice decoding in auditory cortex primarily reflects impulsivity.
(a) Mean choice probability on hit vs. miss trials across all A1 experiments, split by target stimulus signal-to-noise ratio (SNR). Gray shading represents the time when the target sound stimulus is …
Figure 5 with 2 supplements
Task-related changes in shared population covariability do not impact the coding of task-relevant features.
(a) Schematic of population response over many trials to a catch stimulus (gray) and target stimulus (red), projected into a low-dimensional space. Dashed line indicates the sensory discrimination …
Figure 5—figure supplement 1
Modulation of population covariability metrics by task engagement.
Population metrics extracted from factor analysis model fit. Models were fit to the catch stimulus only to control for variability due to stimulus identity. P=passive, A=active. (a) Loading …
Figure 5—figure supplement 2
Modeling task-dependent changes in shared population covariability improves predictions of decoding changes in A1, but not dPEG.
(a) Mean Δd-prime across all target vs. target and target vs. catch stimulus pairs for each factor analysis based simulation: Null model, gain only model, independent variance model, and shared …
