Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis'

  1. James A Watson  Is a corresponding author
  2. Robert J Commons
  3. Joel Tarning
  4. Julie A Simpson
  5. Alejandro Llanos Cuentas
  6. Marcus VG Lacerda
  7. Justin A Green
  8. Gavin CKW Koh
  9. Cindy S Chu
  10. François H Nosten
  11. Richard N Price
  12. Nicholas PJ Day
  13. Nicholas J White  Is a corresponding author
  1. Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Viet Nam
  2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom
  3. WorldWide Antimalarial Resistance Network, United Kingdom
  4. Global Health Division, Menzies School of Health Research, Charles Darwin University, Australia
  5. Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Thailand
  6. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Australia
  7. Unit of Leishmaniasis and Malaria, Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia, Peru
  8. Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Brazil
  9. GSK, United Kingdom
  10. Department of Infectious Diseases, Northwick Park Hospital, United Kingdom
  11. Shoklo Malaria Research Unit, Thailand
1 figure and 1 additional file

Figures

Hypothetical example showing why the Gini criterion does not lead to a split which is clinically relevant in this context.

Under this data generating process, the optimal split for the Gini criterion is at x=0, corresponding to a probability of 0.5 that y=1.

Additional files

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. James A Watson
  2. Robert J Commons
  3. Joel Tarning
  4. Julie A Simpson
  5. Alejandro Llanos Cuentas
  6. Marcus VG Lacerda
  7. Justin A Green
  8. Gavin CKW Koh
  9. Cindy S Chu
  10. François H Nosten
  11. Richard N Price
  12. Nicholas PJ Day
  13. Nicholas J White
(2024)
Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis'
eLife 13:e91283.
https://doi.org/10.7554/eLife.91283