Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

  1. Jean Marc Tsagmo Ngoune
  2. Parul Sharma
  3. Aline Crouzols
  4. Nathalie Petiot
  5. Brice Rotureau  Is a corresponding author
  1. Trypanosome Transmission Group, Trypanosome Cell Biology Unit, Institut Pasteur, Université Paris Cité, France
  2. Sorbonne Université, ED515 Complexité du Vivant, France
  3. Parasitology Unit, Institut Pasteur of Guinea, Guinea
2 figures and 1 additional file

Figures

Stumpy forms are the predominant transmissible forms.

Comparison of (A) midgut and (B) salivary gland infection rates in teneral (T) vs. adult (A) tsetse flies (batches of 50 flies) infected with 10–100 (circles, three independent experiments), 100–1000 (squares, four independent experiments), or 1000–10,000 (triangles, five independent experiments) parasites in the slender (SL in blue) or stumpy (ST in red) forms.

N-acetyl-glucosamine promotes trypanosome infection in teneral flies.

Comparison of midgut infection rates in teneral vs. adult tsetse flies (blue triangles indicate batches of 50 flies, N=3 biological replicates) infected with 1000–10,000 slender parasites with (+) or without (-) N-acetyl-glucosamine (GlucNAc) supplement in the infective meal containing 105 slender parasites/ml (equivalent to 1000–10,000 slender parasites per meal).

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  1. Jean Marc Tsagmo Ngoune
  2. Parul Sharma
  3. Aline Crouzols
  4. Nathalie Petiot
  5. Brice Rotureau
(2025)
Stumpy forms are the predominant transmissible forms of Trypanosoma brucei
eLife 12:RP91602.
https://doi.org/10.7554/eLife.91602.4