Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states
- Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, United States
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Figure 1
This figure provides a schematic diagram of the differences in calcium handling in previously healthy children and adults following acute burn injury and the putative role of phosphate in adults and children.
Note that in children, pro-inflammatory cytokines up-regulate the parathyroid calcium-sensing receptor (CaSR) leading to hypocalcemic hypoparathyroidism and increased urinary calcium excretion, while in adults the up-regulation of the parathyroid CaSR response to pro-inflammatory cytokines is inhibited, possibly due to phosphate binding to the parathyroid CaSR leading to normo-or mildly hypercalcemic hyperparathyroidism and a reduction in urinary calcium excretion.
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Phosphate as an adjunct to calcium in promoting coronary vascular calcification in chronic inflammatory states
eLife 13:e91808.
https://doi.org/10.7554/eLife.91808
