A double dissociation between semantic and spatial cognition in visual to default network pathways
- Department of Psychology, University of York, United Kingdom
- York Neuroimaging Centre, Innovation Way, Heslington, United Kingdom
- School of Human and Behavioural Sciences, Bangor University, Gwynedd, Wales, UK, United Kingdom
- Sussex Neuroscience, School of Psychology, University of Sussex, United States
- Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine Stanford, United Kingdom
- University of Bordeaux, CNRS, CEA, IMN, France
- Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, France
- Department of Psychology, Liverpool John Moores University, United Kingdom
- Integrative Neuroscience and Cognition Center (UMR 8002), Centre National de la Recherche Scientifique (CNRS) and Université de Paris, France
- Department of Psychology, Queen’s University, Kingston, Canada
Figures
Figure 1
Behavioural results for the semantic and spatial context tasks inside the scanner.
SCB = same-category buildings: all the items in the building were taken from the same semantic category. MCB = mixed-category buildings: the items in the buildings were drawn from different semantic …
Figure 2 with 1 supplement
Probe responses.
Warm colours = semantic > spatial context probes. Cool colours = spatial context > semantic probes. Left panel: Univariate results from Study 1, contrasting semantic and spatial context probes. …
Figure 2—figure supplement 1
Left panel: Areas associated with the passive viewing of objects are shown in red, and those associated with the passive viewing of scenes are shown in blue; areas that responded to both objects and scenes are shown in purple.
Right panel: The results of the localiser shown in the left panel were further constrained to contain only voxels that overlapped with the visual networks in Yeo’s 17-network parcellation. Common …
Figure 3
Decision responses.
Warm colours = semantic > spatial context decisions. Cool colours = spatial context > semantic decisions. Left panel: Univariate results from Study 1 contrasting semantic and spatial context …
Figure 4 with 4 supplements
Visual to Default Network Pathways.
(a–c) These panels depict the seeds, regions of interest (ROIs), and their connectivity. The bar plots in (b and c) show the connectivity between default mode network (DMN) decision regions and …
Figure 4—figure supplement 1
Results of the re-analysis of intrinsic connectivity between semantic and context visual probe and default mode network (DMN) decision regions.
Figure 4—figure supplement 2
Connectivity of the default mode network (DMN) decision regions to the object/scene localiser from Study 2, and that of the visual probe regions to fronto-temporal (FT), medial temporal (MT), and core DMN of Yeo’s 17-network parcellation.
Figure 4—figure supplement 3
The y axis of the bar plots shows the percentage of streamlines from each default mode network (DMN) seed that terminate in each visual region of interest (ROI) (shown in the x axis).
Seeds and ROIs can be consulted in Figure 4a. The error bars depict the standard error of the mean.
Figure 4—figure supplement 4
Psychophysiological interaction analysis of the connectivity from the spatial context and semantic probe regions to fronto-temporal (FT) and medial temporal (MT)-default mode network (DMN) subnetworks.
This analysis collapses the same-category building (SCB) and mixed-category building (MCB) conditions, which showed no significant differences. Note: *=p<0.05, **=p<0.01.
Figure 5 with 1 supplement
Analysis situating the position of the pathways in a whole-brain connectivity gradient space (Margulies et al., 2016).
The scatterplots depict the position of each participant’s peak response to the semantic and context task in this gradient space (the big circles represent the mean of each task for that phase). The …
Figure 5—figure supplement 1
Location in the two principal gradients of the peak response per participant for semantic and spatial context decisions.
Dashed lines highlight the cases that contradict the pattern found in the group-level analysis.
Figure 6 with 2 supplements
Univariate results for the probe phase contrasting same-category versus mixed-category trials separately for the semantic and spatial context tasks.
(a) Contrast of spatial context same- > mixed-category building trials during the probe phase. (b) Task by condition (same/mixed-category building) interaction. (c) Contrast of semantic same- > …
Figure 6—figure supplement 1
Results of the representational similarity analysis (RSA).
Top left panel: Within-task RSA results correlating BOLD activity from the probe phase of semantic mixed-category building trials with the semantic similarity matrix described in the Methods …
Figure 6—figure supplement 2
Representational similarity analysis results for the same-category building trials of the probe phase of the semantic task.
No significant voxels were identified for the spatial context task.
Figure 7 with 2 supplements
Top panel: the layout of two buildings is shown, one of them contains semantically related items (same-category building [SCB]), the other contains unrelated items (mixed-category building [MCB]).
These items and locations are shown in the example trials below. Bottom panel: Trial procedure for semantic and spatial context decisions. The phases of a trial are shown (probe, dots, decision, …
Figure 7—figure supplement 1
Top panel: An example of what was seen during the training videos.
This is a ‘mixed-category building’ that contains items from different semantic categories. An example walk-through video of this building can be watched following this link: https://www.youtube.com/…
Figure 7—figure supplement 2
Examples of the dynamic images taken from the 3 s movie clips depicting faces, bodies, scenes, objects, and scrambled objects.
Still images taken from the beginning, middle, and end of the corresponding movie clip. The stimuli corresponding to the ‘faces’ condition were changed to line drawings to make this material …
Additional files
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MDAR checklist
- https://cdn.elifesciences.org/articles/94902/elife-94902-mdarchecklist1-v1.docx
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Supplementary file 1
Cluster Information for Neuroimaging Results from Study 1.
- https://cdn.elifesciences.org/articles/94902/elife-94902-supp1-v1.docx
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Supplementary file 2
Paired t-tests contrasting spatial similarity of participant-level activation with group-level context and semantic pathways and non-pathways.
- https://cdn.elifesciences.org/articles/94902/elife-94902-supp2-v1.docx
