Unraveling the impact of congenital deafness on individual brain organization
- Department of Neuroscience, Georgetown University Medical Center, United States
- State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, China
- Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, China
- Chinese Institute for Brain Research, China
Figures
Figure 1 with 1 supplement
Individual differences in functional connectivity (FC) from the auditory cortex (AC) increase in deafness.
(A) Significant differences in the interindividual variability of the AC-FC values between deaf and hearing groups (p<0.05, cluster-corrected for multiple comparisons) are presented on inflated …
Figure 1—figure supplement 1
Auditory cortex functional connectivity (AC-FC) variability difference between delayed signing deaf and hearing individuals.
(A) Differences in delayed signing deaf subgroup and hearing group in their interindividual variability of the AC-FC values (p<0.05, cluster-corrected for multiple comparisons). (B) The ratio of the …
Figure 2
Individual variability in deafness is related to brain plasticity.
(A) ANOVA main effect showing which regions are reorganized in deafness (group difference between the deaf and hearing in auditory cortex functional connectivity [AC-FC]) (p<0.05, cluster-corrected …
Figure 3
Auditory cortex functional connectivity (AC-FC) variability is influenced by language exposure.
(A) Differences between delayed and native signing deaf subgroups in their interindividual variability of the AC-FC values (p<0.05, cluster-corrected for multiple comparisons) show changes to …
Appendix 1—figure 1
To test if increased variability in deafness was unique to the auditory system, we calculated inter-individual variability using all regions from the Harvard-Oxford Atlas, excluding auditory and language regions, as control seed regions for the functional connectivity (FC) analysis.
FC variability from the seed areas to the whole brain was calculated for the Auditory Cortex (AC) and control regions. The plot shows the number of voxels with a significant Brown-Forsythe effect …
Appendix 1—figure 2
Correlation to hearing aid age and hearing threshold.
(A) Auditory Cortex Functional Connectivity (AC-FC) to different regions is positively correlated to the age of deaf participants started using hearing aids (N=28). (B) AC-FC to the fusiform gyrus …
Appendix 1—figure 3
Scatter plots depicting the correlation between auditory cortex functional connectivity (AC-FC) mean values and hearing thresholds across various brain regions in deaf participants.
The x-axis represents the hearing threshold (in decibels), while the y-axis represents the AC-FC mean value for the cluster. Each purple dot indicates individual participant data points, and the red …
Appendix 1—figure 4
Scatter plots depicting the correlation between auditory cortex functional connectivity (AC-FC) mean values and age at which hearing aids were first used across various brain regions in deaf participants.
The x-axis represents the hearing aids age in years while the y-axis represents the AC-FC mean value for the cluster. Each purple dot indicates individual participant data points, and the red line …
Appendix 1—figure 5
Scatter plots depicting the correlation between auditory cortex functional connectivity (AC-FC) mean values and duration of hearing aids use across various brain regions in deaf participants.
The x-axis represents the duration of hearing aids use (in years), while the y-axis represents the AC-FC mean value for the cluster. Each purple dot indicates individual participant data points, and …
Tables
Table 1
Participants’ demographic information.
| Native deaf signers (N=16) | Delayed deaf signers (N=23) | Hearing nonsigners (N=33) | |
|---|---|---|---|
| Age of sign language acquisition | 0±0 | 6.91±1.62 | N/A |
| Age | 28.50±7.13 | 27.09±5.87 | 21.97±2.54 |
| Years of education | 14.13±2.31 | 15.09±1.41 | 15.03±1.93 |
| Gender | 11 M, 5 F | 12 M, 11 F | 15 M, 18 F |
Additional files
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Supplementary file 1
MNI coordinates (x, y, z) for the functional connectivity (FC) variability analyses.
- https://cdn.elifesciences.org/articles/96944/elife-96944-supp1-v1.docx
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Supplementary file 2
Additional characteristics of deaf participants.
- https://cdn.elifesciences.org/articles/96944/elife-96944-supp2-v1.docx
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MDAR checklist
- https://cdn.elifesciences.org/articles/96944/elife-96944-mdarchecklist1-v1.docx
