(a, k) Schemes and pictures show the general set-up for the electrophysiological recordings and pairing protocol (∆t = –18ms, time between the peak of the postsynaptic spike and the onset of the …
Individual values included in the histograms.
(a and c) Time course of EPSP monitored in slices during baseline and after the addition of bicuculline (LPP-GC: 67 ± 6%, n=6; MPP-GC: 65 ± 8%, n=6) and SCH50911 (LPP-GC: 69±11, n=6; MPP-GC: 75 ± …
Individual values included in the histograms of Figure 1—figure supplement 1.
The t-LTD at LPP-GC synapses does not require NMDAR but requires mGluR5.(a) The addition of D-AP5 (50 μM) or MK-801 (500 μM) to the superfusion fluid does not prevent the induction of t-LTD at …
Individual values included in the histograms of Figure 2.
(a) The induction of t-LTD at LPP-GC synapses in slices was unaffected by exposure to nimodipine (10 µM) or to heparin (5 mg/ml), but it was prevented by treatment with thapsigargin (1–10 µM) or …
Individual values included in the histograms of Figure 3.
(a) t-LTD requires postsynaptic calcineurin at LPP-GC synapses. The EPSP slopes monitored in control slices (black triangles, n=9) and in slices treated with the calcineurin blocker FK506 (1–10 µM), …
Individual values included in the histograms of Figure 3—figure supplement 1.
(a, f) Schemes showing the general experimental set-up: A, astrocyte; CA, cornus ammonis; DG, dentate gyrus; EC, entorhinal cortex; GC, granule cell; S1 and S2, stimulating electrodes; R1 and R2, …
Individual values included in the histograms of Figure 4.
(a) Low magnification infrared video microscopy image showing a brain slice with a recording electrode on one astrocyte. (b) Voltage responses of typical astrocytes in the surrounding of LPP-and …