Image credit: D Sharon Pruitt (CC BY 2.0)
Falling asleep affects our behavior immediately and profoundly. During sleep, large electrical waves appear across the brain in areas responsible for consciousness, sensation and movement. In the cortex – the outer layer of the brain – sleep waves arise from networks that connect to the thalamus, a deeper structure within the brain. However, not all areas of the brain sleep equally. We know this intuitively because sensory stimuli, such as an alarm clock or a baby’s cry, can still wake us up. By contrast, we typically do not move much or take major decisions while we sleep. Therefore, the brain areas involved in sensation should not be expected to sleep in the same way as areas involved in movement or reasoning.
Neighboring brain areas generally show very different sleep waves. The brain regions that we use during the day can also affect how sleep varies from one area to the next. It is not well understood what determines these ‘local’ sleep properties.
By studying the brains of mice, Fernandez et al. now show that the networks between the cortex and thalamus are much more varied than previously thought, in particular regarding a thalamic nucleus that is relevant for sleep wave generation. These previously unrecognized differences deep within the brain are part of the origin of local sleep in the outer layer of the brain. Sleep wave activity differed depending on whether the networks were involved in sensory or non-sensory roles. The networks allow sensory areas to switch efficiently between different forms of local sleep. This might underlie how the brain’s sensory activity during the day can influence local sleep at night.
There is growing evidence that major sleep disorders are due to disturbances to local sleep. Techniques to modify or restore specific sleep waves locally in the brain could help to develop new sleep therapies. For example, having a detailed map of electrical waves within the sleep-disordered brain could help researchers to apply transcranial stimulation techniques in ways that might help to treat these debilitating disorders.
