Reactivated activity proportions are decreased in targeted ventral hippocampal regions following inescapable shock.
(A) There is a trending decrease in global co-labeled / c-Fos+ cell proportions between context trained (CT) or inescapable shock (IS) groups. Regional activation analysis of targeted (B) isocortical areas (ACA, AI, RSP), (C) dorsal hippocampal regions (dDG, dCA3, dCA1), (D) ventral hippocampal regions (vDG, vCA3, vCA1), and (E) amygdalar areas (LA, BLA, BMA, CEA) reveal that vDG, vCA3, and vCA1 activity are significantly decreased in IS mice compared to CT mice. Correlation analysis of co-labeled / c-Fos+ activity of targeted isocortical areas, such as the (F) ACA, (G) AI, and (H) RSP, reveal that ACA activity is significantly correlated with crossing latency in the CT group. Analysis of targeted dorsal and ventral hippocampal regions, such as the (I) dDG, (J) dCA1, (K) dCA3, (L) vDG, (M) vCA1, (N) and vCA3, reveal that reveal that vCA1 co-labeled / c-Fos+ is significantly correlated with crossing latency in the CT group. Analysis of targeted amygdalar regions, such as (O) LA, (P) BLA, (Q) BMA, (R) CEA, (S) MEA reveal that reveal that co-labeled / c-Fos+ activity in the BMA and MEA is significantly correlated with crossing latency in the CT group. Error bars represent ± SEM. Per brain region, n = 4-5 mice for the CT group and n = 5-6 for the IS group. ACA, anterior cingulate area; AI, agranular insula; RSP, retrosplenial area; dDG, dorsal dentate gyrus; dCA3, dorsal CA3; dCA1, dorsal CA1; vDG, ventral dentate gyrus; vCA3, ventral CA3; vCA1, ventral CA1; LA, lateral amygdalar nucleus; BLA, basolateral amygdalar nucleus; BMA, basomedial amygdalar nucleus; CEA, central amygdalar nucleus; MEA, medial amygdalar nucleus.