Figures and data
Genetic ancestry analyses of Tanzanian TB patients.
A) Genetic ancestry proportions of the 1,444 Tanzanian TB patients and representative human populations who shared at least 1% of their most common genetic ancestry with the Tanzanians for K = 24. (ESN: Esan from Nigeria (1000G), LWK: Luhya from Kenya (1000G)). For all populations included in our study, see Supplementary Figure S2 for their geographic distribution and S5 for the ancestry composition of all African populations included in this study. B) The geographical location of the representative populations shown in A are depicted with black circles, and the corresponding country is highlighted. The remaining African populations included in the analysis are represented by blue circles.
Spatial visualizations of the Bantu genetic ancestries and the genetic ancestries of the different self-identified ethnic groups among the TB patients in Tanzania. The genetic ancestry was inferred by admixture with K = 24, and the interpolation of the ancestries was performed by using the pykrige module in Python (see methods). A) Eastern Bantu genetic ancestry, B) Southeastern Bantu genetic ancestry, and C) Western Bantu genetic ancestry. The populations included for spatial interpolations are marked with a black dot on the maps. The maps were created using the basemap module in Python. D) Geographical origin of the ethnic groups among our TB patient cohort. The Temeke Distric hospital in Dar es Salaam where the patients were recruited is marked with a red point. Note that for some ethnic groups, no geographical origin could be identified (Supplementary Table 1). E) Ancestry plots for the different ethnic groups with at least 10 patients from our TB patient cohort.
Human and bacterial genotypes by the severity measures.
Summary of ancestry proportions, sociodemographic and clinical data stratified by MTBC genotype.
