Figures and data
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Training induced plasticity of hippocampal subfield volume.
A) Training modules; B) Training design; C) Subfield volumes in left and right hemispheres across individuals and timepoints; D) Scatterplot of subfield volumes as a function of timepoints and training cohorts.
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Changes in mean CA1-3 functional network between training and active control cohorts [T0-T1] and [T1-T3].
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Training induced plasticity of CA1-3 functional connectivity.
A) upper: CA1-3 functional connectivity at baseline, top 10% of regions representing the CA1-3 functional network; lower: scatter plot visualizing change within the CA1-3 network across timepoints and groups; networks and scatters of SUB and CA4/DG are available in the supplements; B) Regional change within CA1-3 functional network Affect versus Perspective (FDRq<0.05); right: scatter plot visualizing mean change within the CA1-3, FDRq<0.05 regions across timepoints and groups.
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Correlating change in CA1-3 subfield volume and diurnal cortisol indices in Affect.
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Correlating change in CA1-3 subfield functional network and diurnal cortisol indices in Affect.
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Associations between changes in structure and function of hippocampal subfield volume and markers of stress change.
A). Upper left: Correlation between hippocampal subfield volume change in Affect and CAR, slope, and AUC markers of stress change, Upper right: Correlation between hippocampal subfield intrinsic functional change in Affect and CAR, slope, and AUC markers of stress change, middle: Scatter plots visualize the correlation between volume change and cortisol marker change (below p<0.05), bottom: region level change within left CA1-3, FDRq<0.05. CA1-3 is the focus of this analysis based on our group-level findings and highlighted with boxes in A; B). Upper: Overall impact of diurnal cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective; Lower: Overall impact of hair cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective
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Multivariate PLS analyses linking cortisol markers to hippocampal subfield volume and function.
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Multivariate associations between changes in structure and function of hippocampal subfield volume and markers of stress change in Affect.
A). Multivariate associations between bilateral CA1-3 volume and intrinsic function and stress markers. Left: Scatter of loadings, colored by Training Module; Right upper: individual correlations of stress markers; Right lower: individual correlation of subfields; B). Multivariate associations between all subfields’ volume and intrinsic function and stress markers. Left: Scatter of loadings, colored by Training Module; Right upper: individual correlations of stress markers; Right lower: individual correlation of subfields.
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Sample size per timepoint.
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Reason for missing data across the study duration.
MR incidental findings are based on T0 radiological evaluations; participants who did not meet MRI quality control criteria refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (71); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed; functional MRI missing: no complete functional MRI; functional MRI quality: >0.3mm movement (low quality in volume + surface)
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Reason for missing data across the study duration.
MR incidental findings are based on T0 radiological evaluations; participants who did not survive MRI quality control refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (71); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed.
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