Figures and data
Training induced plasticity of hippocampal subfield volume.
A) Training modules; B) Training design; C) Subfield volumes in left and right hemispheres across individuals and timepoints; D) Scatterplot of subfield volumes as a function of timepoints and training cohorts.
Changes in mean CA1-3 functional network between training and active control cohorts [T0-T1] and [T1-T3].
Training induced plasticity of CA1-3 functional connectivity.
A) upper: CA1-3 functional connectivity at baseline, top 10% of regions representing the CA1-3 functional network; lower: scatter plot visualizing change within the CA1-3 network across timepoints and groups; networks and scatters of SUB and CA4/DG are available in the supplements; B) Regional change within CA1-3 functional network Affect versus Perspective (FDRq<0.05); right: scatter plot visualizing mean change within the CA1-3, FDRq<0.05 regions across timepoints and groups.
Correlating change in CA1-3 subfield volume and diurnal cortisol indices in Affect.
Correlating change in CA1-3 subfield functional network and diurnal cortisol indices in Affect.
Associations between changes in structure and function of hippocampal subfield volume and markers of stress change.
A). Upper left: Correlation between hippocampal subfield volume change in Affect and CAR, slope, and AUC markers of stress change, Upper right: Correlation between hippocampal subfield intrinsic functional change in Affect and CAR, slope, and AUC markers of stress change, middle: Scatter plots visualize the correlation between volume change and cortisol marker change (below p<0.05), bottom: region level change within left CA1-3, FDRq<0.05. CA1-3 is the focus of this analysis based on our group-level findings and highlighted with boxes in A; B). Upper: Overall impact of diurnal cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective; Lower: Overall impact of hair cortisol markers on hippocampal subfield volume and function over Presence, Affect and Perspective
Multivariate PLS analyses linking cortisol markers to hippocampal subfield volume and function.
Multivariate associations between changes in structure and function of hippocampal subfield volume and markers of stress change in Affect.
A). Multivariate associations between bilateral CA1-3 volume and intrinsic function and stress markers. Left: Scatter of loadings, colored by Training Module; Right upper: individual correlations of stress markers; Right lower: individual correlation of subfields; B). Multivariate associations between all subfields’ volume and intrinsic function and stress markers. Left: Scatter of loadings, colored by Training Module; Right upper: individual correlations of stress markers; Right lower: individual correlation of subfields.
Sample size per timepoint.
Reason for missing data across the study duration.
MR incidental findings are based on T0 radiological evaluations; participants who did not meet MRI quality control criteria refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (71); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed; functional MRI missing: no complete functional MRI; functional MRI quality: >0.3mm movement (low quality in volume + surface)
Reason for missing data across the study duration.
MR incidental findings are based on T0 radiological evaluations; participants who did not survive MRI quality control refers to movement and/or artefacts in the T1-weighted MRI; dropout details can be found in (71); no MRT: due to illness / scheduling issues / discomfort in scanner; other: non-disclosed.
