Associations of genetic liability to adult colorectal cancer (based on a 72 SNP genetic risk score) with clinically validated metabolic traits at different early life stages among ALSPAC offspring (age 8y (N=4,767), 16y (N=2,930), 18y (N=2,613), and 25y (N=2,559)). Estimates shown are beta coefficients representing the SD difference in metabolic trait per doubling of genetic liability to colorectal cancer (purple, 8y; turquoise, 16y; red, 18y; black, 25y). Filled point estimates are those that pass a Benjamini–Hochberg FDR multiple-testing correction (FDR < 0.05).