Clinical characteristics of patients admitted to hospital with infections.

Association between APOL1 high-risk genotypes and the risk of sepsis, and septic shock, and individual sepsis organ dysfunction criteria.

Analyses were adjusted for age, sex and 3PCs. Sepsis was defined as meeting the Sepsis-3 criteria for sepsis,23,24 septic shock was defined using ICD9 and 10 codes for septic shock/severe sepsis (ICD-9-CM, 995.92 and 785.52; ICD-10-CM, R65.20 and R65.21); organ dysfunction data represent the individual organ dysfunction criteria in the Sepsis-3 definition; death was defined as in-hospital death or discharge to hospice.

Associations between APOL1 high-risk genotypes and the risk of sepsis and renal dysfunction before and after adjustment for renal disease, and exclusion of patients with pre-existing severe renal disease.

We test the associations between APOL1 high-risk genotypes and the risk of sepsis (a, b, c) or the risk of sepsis-related renal dysfunction (d, e, f). Sepsis was defined as meeting the Sepsis-3 criteria for sepsis,23,24 sepsis-related renal dysfunction represents the individual organ dysfunction criteria in the Sepsis-S3 definition. Analyses (a) and (d) were adjusted for age, sex, and 3 PCs. * In analyses (b) and (e) we adjusted for age, sex, 3 PCs, and pre-existing severe renal disease. **In analyses (c) and (f), we excluded patients with pre-existing severe renal disease and adjusted for age, sex, and 3 PCs.

Cross-sectional restricted PheWAS associations between APOL1 high-risk genotype and sepsis-related phenotypes.

We tested the associations between APOL1 high-risk genotype and sepsis-related phenotypes, including infection of internal prosthetic device, systemic inflammatory response syndrome [SIRS], sepsis, septic shock, and septicemia. We conduct the analyses in all EHR-reported Black individuals with available MEGAEX genotypes in BioVU (n=14,713, panel A) and after excluding individuals with severe renal diseases (n=12,547, panel B). Analyses were adjusted for age, sex, and 3 PCs.