Clinical characteristics of patients admitted to the hospital with infections

Association between APOL1 high-risk genotypes and the risk of sepsis, and septic shock, and individual sepsis organ dysfunction criteria

Analyses were adjusted for age, sex and 3 principal components (PCs). Sepsis was defined as meeting the Sepsis-3 criteria for sepsis,(29, 30) septic shock was defined using ICD9 and 10 codes for septic shock/severe sepsis (ICD-9-CM, 995.92 and 785.52; ICD-10-CM, R65.20 and R65.21); organ dysfunction data represent the individual organ dysfunction criteria in the Sepsis-3 definition; short-term mortality was defined as in-hospital death or discharge to hospice.

Associations between APOL1 high-risk genotypes and the risk of sepsis and renal dysfunction before and after adjustment for renal disease, and exclusion of patients with pre-existing severe renal disease

We test the associations between APOL1 high-risk genotypes and the risk of sepsis (a, b, c) or the risk of sepsis-related renal dysfunction (d, e, f). Sepsis was defined as meeting the Sepsis-3 criteria for sepsis,(29, 30) sepsis-related renal dysfunction represents the individual organ dysfunction criteria in the Sepsis-S3 definition. Analyses (a) and (d) were adjusted for age, sex, and 3 PCs. * In analyses (b) and (e) we adjusted for age, sex, 3 principal components, and pre-existing severe renal disease. **In analyses (c) and (f), we excluded patients with pre-existing severe renal disease and adjusted for age, sex, and 3 principal components.

Restricted PheWAS associations between APOL1 high-risk genotype and sepsis-related phenotypes

We tested the associations between APOL1 high-risk genotype and sepsis-related phenotypes, including infection of internal prosthetic device, systemic inflammatory response syndrome [SIRS], sepsis, septic shock, and septicemia. We conduct the analyses in all EHR-reported Black individuals with available MEGAEX genotypes in BioVU (n=14,713, panel A) and after excluding individuals with severe renal diseases (n=12,547, panel B). Analyses were adjusted for age, sex, and 3 principal components.